Multiple, not just Beta–Gamma, phase-amplitude couplings are associated with Parkinson’s disease and related intervention effects

IF 3.4 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-11 DOI:10.1016/j.clinph.2025.2111425

Alireza Kazemi , Salar Nouri , Maryam S. Mirian , Soojin Lee , Martin J. McKeown

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引用次数: 0

Abstract

Objective

1) To evaluate the importance of various EEG Phase Amplitude Couplings (PACs) in predicting motor vigor (MV) in Parkinson’s Disease (PD). 2) To determine the effects of dopaminergic medication and non-invasive galvanic vestibular stimulation (GVS) on MV-related PACs.

Methods

EEG data from 18 PD patients in comparison to 20 HC controls, executing a simple overlearned handgrip task was used, to identify PD-specific alterations. A deep learning model, PACNET, based on the VGG-16 architecture, was used to predict MV from a visual representation of different PACs.

Results

Delta-Beta, Theta-, Alpha-, and Beta-Gamma PACs were important for MV prediction. In PD subjects, GVS affected Delta-Beta, and Theta-, Beta- Gamma PAC’s role in MV prediction in a stimulation-specific manner. Delta-Beta and Theta-Gamma PACs were more relevant for PD patients’ MV prediction after L-dopa medication.

Conclusions

Multiple PACs are important for MV in Parkinson’s disease. Therapeutic interventions affect PAC/MV associations.

Significance

Multiple PACs, not just Beta–Gamma, are important for MV in PD and may serve as targets for neuromodulation strategies. A combined assessment of PACs could be a valuable biomarker for both disease evaluation and therapeutic effects in PD.

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多重，而不仅仅是β - γ，相位振幅耦合与帕金森病和相关干预效果有关

目的1)评价各种EEG相幅耦合（PACs）在预测帕金森病（PD）运动活力（MV）中的重要性。2)探讨多巴胺能药物治疗和无创前庭电刺激（GVS）对mv相关PACs的影响。方法18例PD患者的seeg数据与20例HC对照，执行简单的过度学习握拳任务，以确定PD特异性改变。基于VGG-16架构的深度学习模型PACNET用于从不同pac的视觉表示中预测MV。结果δ - β、θ -、α -和β - γ PACs对MV预测有重要意义。在PD受试者中，GVS以刺激特异性的方式影响Delta-Beta、Theta-、Beta- Gamma PAC在MV预测中的作用。δ - β和θ - γ PACs与左旋多巴治疗后PD患者的MV预测更相关。结论多个PACs在帕金森病的MV中起重要作用。治疗干预影响PAC/MV关联。多种pac，而不仅仅是β - γ，对PD的MV很重要，可能作为神经调节策略的靶点。PACs的联合评估可能是PD疾病评估和治疗效果的有价值的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.