Oxygen therapy enhances the systemic inflammatory response in a human model of experimental inflammation

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

IJC Heart and Vasculature Pub Date : 2026-02-01 Epub Date: 2025-11-28 DOI:10.1016/j.ijcha.2025.101846

P. Tornvall , P. Svensson , J. Alfredsson , L. Jonasson , L. Nilsson , R. Hofmann , SK. Merid

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引用次数: 0

Abstract

Introduction

Oxygen therapy does not benefit normoxemic patients with suspected myocardial infarction and may instead enhance the inflammatory response triggered by the tissue necrosis caused by the myocardial infarction. In the present study, we tested the hypothesis that oxygen therapy aggravates systemic inflammation in normoxemic healthy individuals in a human model of experimental inflammation.

Methods

Proteomic and gene expression data from healthy subjects vaccinated against Salmonella Typhii and exposed to oxygen therapy or ambient air were investigated. A multi-omics approach with factor analysis to identify common sources of variation in the systemic inflammatory response associated with oxygen exposure was used.

Results

Oxygen therapy showed a statistically nominal tendency toward aggravation determined by ELISA (IL-6) and proximity extension assay (IL-8). The factor analysis revealed a pro-inflammatory feature that included increases in (CXCL 6, 10 and 11) with decreased small nucleolar RNA.

Conclusion

The results indicate that oxygen therapy enhances experimental systemic inflammation. The mechanism is not clear but future studies should address small nucleolar RNA.

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氧治疗增强了人体实验炎症模型的全身炎症反应

氧疗对怀疑心肌梗死的等氧血症患者没有益处，反而可能增强心肌梗死引起的组织坏死引发的炎症反应。在本研究中，我们在实验炎症的人体模型中验证了氧气治疗加重等氧血症健康个体全身性炎症的假设。方法对接种伤寒沙门菌和暴露于氧疗或环境空气的健康受试者进行蛋白质组学和基因表达分析。采用多组学方法和因子分析来确定与氧暴露相关的全身炎症反应的常见变异源。结果ELISA （IL-6）和邻近扩展试验（IL-8）检测结果显示，氧治疗有统计学意义上的加重倾向。因子分析显示促炎特征包括（cxcl6、10和11）增加，小核仁RNA减少。结论氧疗可增强实验性全身炎症反应。其机制尚不清楚，但未来的研究应针对小核RNA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

10.30%

发文量

216

审稿时长

56 days

期刊介绍： IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.