Acute kidney and liver injury requiring hemodialysis following cathinone use in a person with HIV.

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

HIV Research & Clinical Practice Pub Date : 2025-12-31 Epub Date: 2025-11-26 DOI:10.1080/25787489.2025.2588012

Lucia Federica Stefanelli, Dorella Del Prete, Leda Cattarin, Elena Naso, Maria Loreta De Giorgi, Elena Sgrò, Ludovica Brunetta, Francesca Katiana Martino, Annamaria Cattelan, Federico Nalesso, Maria Mazzitelli

{"title":"Acute kidney and liver injury requiring hemodialysis following cathinone use in a person with HIV.","authors":"Lucia Federica Stefanelli, Dorella Del Prete, Leda Cattarin, Elena Naso, Maria Loreta De Giorgi, Elena Sgrò, Ludovica Brunetta, Francesca Katiana Martino, Annamaria Cattelan, Federico Nalesso, Maria Mazzitelli","doi":"10.1080/25787489.2025.2588012","DOIUrl":null,"url":null,"abstract":"Introduction: Chemsex drugs are psychoactive substances used to facilitate and enhance sexual activity. Their use is frequent among men who have sex with men (MSM). Synthetic cathinones have been the most common drugs recently used in chemsex practice. After their intake, the clinical spectrum may include tachycardia, hypertension, hallucinations, seizures, hyperthermia, rhabdomyolysis with resulting nephrotoxicity, and potentially life-threatening multiorgan failure.Case presentation: Here, we report the case of a gentleman with HIV who came to observe severe rhabdomyolysis and acute kidney injury (AKI) following the use of Khat.Conclusion: This case highlights that clinicians need to be vigilant about the adverse effects of synthetic cathinones used in the context of chemsex as a possible cause of AKI. To the best of our knowledge, this is the ﬁrst reported case of AKI caused by cathinone toxicity successfully treated in Italy.","PeriodicalId":13165,"journal":{"name":"HIV Research & Clinical Practice","volume":"26 1","pages":"2588012"},"PeriodicalIF":2.1000,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"HIV Research & Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/25787489.2025.2588012","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Chemsex drugs are psychoactive substances used to facilitate and enhance sexual activity. Their use is frequent among men who have sex with men (MSM). Synthetic cathinones have been the most common drugs recently used in chemsex practice. After their intake, the clinical spectrum may include tachycardia, hypertension, hallucinations, seizures, hyperthermia, rhabdomyolysis with resulting nephrotoxicity, and potentially life-threatening multiorgan failure.

Case presentation: Here, we report the case of a gentleman with HIV who came to observe severe rhabdomyolysis and acute kidney injury (AKI) following the use of Khat.

Conclusion: This case highlights that clinicians need to be vigilant about the adverse effects of synthetic cathinones used in the context of chemsex as a possible cause of AKI. To the best of our knowledge, this is the ﬁrst reported case of AKI caused by cathinone toxicity successfully treated in Italy.

查看原文本刊更多论文

艾滋病毒感染者卡西酮使用后需要血液透析的急性肾和肝损伤。

导言：性化学药物是用于促进和增强性活动的精神活性物质。它们在男男性行为者（MSM）中很常见。合成卡西酮是近年来在化学性实践中最常用的药物。服用后，临床表现可能包括心动过速、高血压、幻觉、癫痫发作、高热、横纹肌溶解导致肾毒性和可能危及生命的多器官衰竭。病例介绍：在这里，我们报告了一位患有艾滋病毒的绅士，他在使用阿拉伯茶后观察严重横纹肌溶解和急性肾损伤（AKI）。结论：该病例强调，临床医生需要警惕化学行为中使用的合成卡西酮的不良反应，因为它可能是AKI的原因。据我们所知，这是意大利首例成功治疗卡西酮毒性引起AKI的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

HIV Research & Clinical Practice Multiple-

CiteScore

2.90

自引率

6.20%

发文量