Metabolomics-Based Diagnosis of Medullary Thyroid Cancer: A Plasma 1H NMR Approach.

IF 1.9 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Iranian Journal of Public Health Pub Date : 2025-09-01 DOI:10.18502/ijph.v54i9.19867

Khadijeh Saeidi, Mehdi Hedayati, Monireh Movahedi, Maryam Sadat Daneshpour

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Abstract

Background: Medullary thyroid cancer (MTC) is a rare neuroendocrine malignancy, accounting for 5-10% of all thyroid cancer cases. The precise molecular processes driving MTC remain largely elusive. We aimed to conduct a pilot study analyzing plasma metabolic profiles of MTC patients to uncover disruptions in metabolic pathways that may contribute to MTC tumorigenesis.

Methods: Proton nuclear magnetic resonance (1H-NMR) spectroscopy was performed to screen metabolic changes in plasma samples from MTC patients (n=16) and healthy subjects (n=12). Multivariate and univariate analyses were applied using MetaboAnalyst and SIMCA software.

Results: A total of 30 compounds were identified, of which three metabolites-glycerol, isobutyric acid, and valine-showed significant differences between MTC patients and the control group (P<0.05).

Conclusion: The findings from this study contribute to the current understanding of MTC metabolism and suggest that the NMR-based metabolomics approach can provide a metabolic pattern of MTC, potentially improving diagnostic procedures.

Abstract Image

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基于代谢组学的甲状腺髓样癌诊断：血浆1H NMR方法。

背景：甲状腺髓样癌（MTC）是一种罕见的神经内分泌恶性肿瘤，约占甲状腺癌病例的5-10%。驱动MTC的精确分子过程在很大程度上仍然难以捉摸。我们的目的是进行一项初步研究，分析MTC患者的血浆代谢谱，以发现可能导致MTC肿瘤发生的代谢途径的中断。方法：采用质子核磁共振（1H-NMR）技术，对16例MTC患者和12例正常人血浆样品进行代谢变化检测。采用MetaboAnalyst和SIMCA软件进行多因素和单因素分析。结果：共鉴定出30种化合物，其中3种代谢物——甘油、异丁酸和缬氨酸在MTC患者和对照组之间表现出显著差异(结论：本研究的发现有助于目前对MTC代谢的理解，并表明基于核磁共振的代谢组学方法可以提供MTC的代谢模式，有可能改善诊断程序。

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来源期刊

Iranian Journal of Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

2.20

自引率

7.10%

发文量

300

审稿时长

3-8 weeks

期刊介绍： Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.