WNT5A in ovarian physiology and pathology: from molecular mechanisms to therapeutic potential.

IF 1.9 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-11-25 eCollection Date: 2025-12-01 DOI:10.1515/hmbci-2025-0034

Qing Gao, Jiang Fu

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Abstract

Introduction: As a pivotal molecule in tissue development and homeostasis, WNT5A regulates various aspects of ovarian physiology, including folliculogenesis, oocyte maturation, and hormonal responses.

Content: This review summarizes current knowledge on the molecular mechanisms of WNT5A signaling, its role in ovarian health, and its pathological involvement in disorders such as polycystic ovary syndrome (PCOS) and ovarian cancer. We discuss how WNT5A may be a double-edged sword in ovarian diseases and explore its therapeutic potential.

Summary: In PCOS, WNT5A exacerbates the inflammatory environment and insulin resistance, disrupting normal folliculogenesis and leading to impaired ovarian function. Moreover, in ovarian cancer, WNT5A presents challenges for therapeutic targeting, as it can either inhibit or facilitate tumor progression depending on the context.

Outlook: Continued research into the peripheral and central regulatory mechanisms of WNT5A, along with its interactions with other signaling pathways, will be instrumental in unlocking its full therapeutic potential.

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WNT5A在卵巢生理病理中的作用：从分子机制到治疗潜力

简介：WNT5A作为组织发育和体内平衡的关键分子，调节卵巢生理的各个方面，包括卵泡发生、卵母细胞成熟和激素反应。内容：本文综述了WNT5A信号通路的分子机制、在卵巢健康中的作用及其在多囊卵巢综合征（PCOS）和卵巢癌等疾病中的病理参与。我们讨论WNT5A在卵巢疾病中如何成为一把双刃剑，并探讨其治疗潜力。摘要：在PCOS中，WNT5A加重炎症环境和胰岛素抵抗，破坏正常卵泡发生，导致卵巢功能受损。此外，在卵巢癌中，WNT5A对治疗靶向提出了挑战，因为它可以根据具体情况抑制或促进肿瘤进展。展望：继续研究WNT5A的外周和中枢调节机制，以及它与其他信号通路的相互作用，将有助于释放其全部治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.