{"title":"Comprehensive Bibliometric Analysis of P-Tau in Alzheimer's Disease: Trends and Emerging Research Priorities (1991-2024).","authors":"Xing Wang, Ying Shen, Chao Lei, Juan Chai, Qian Tan, Yanqiong Qin","doi":"10.1159/000549394","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>As a major contributor to dementia burden worldwide, Alzheimer's disease (AD) pathogenesis involves critical phosphorylated tau (p-tau) abnormalities. This research employed bibliometric methods to systematically evaluate worldwide scientific trends, emerging foci, and international collaboration patterns regarding p-tau in AD research.</p><p><strong>Methods: </strong>Relevant publications spanning 1991-2024 from the Web of Science Core Collection were extracted. Bibliometric analysis was performed using R package \"Bibliometrix\" (v4.3.3), CiteSpace (v6.1.R2) and VOSviewer (v1.6.20).</p><p><strong>Results: </strong>A total of 2,685 publications were included. China led in publication volume (612, 22.8%), followed by the USA (586, 21.8%) and Sweden (212, 7.9%). University of London was the most productive institution (603 publications). Blennow Kaj stood out with publications and citations of 270 and 18,093. The Journal of Alzheimer's Disease and Neurology were the top-ranked journal, with the highest publications (321) and citations (6,446), respectively. Cluster analysis revealed four major clusters, including mechanisms underlying p-tau in AD, p-tau as biomarker in AD, diagnosis of AD using p-tau, and consensus in AD. Keyword burst analysis emphasized recent terms such as \"neurofilament light,\" \"dysfunction,\" \"performance,\" and \"biomarker.\"</p><p><strong>Conclusion: </strong>This study systematically analyzed the researches on p-tau in AD. Research hotspots have evolved from the early focus on pathological features to the exploration of biomarkers-based diagnosis. Recently, the comprehensive assessment AD is emphasized, suggesting that future studies should pay more attention to regulatory mechanism of abnormal p-tau for identification of therapeutic targets and overcome the challenges of p-tau as biomarkers during clinical diagnosis.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"289-302"},"PeriodicalIF":2.5000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dementia and Geriatric Cognitive Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000549394","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: As a major contributor to dementia burden worldwide, Alzheimer's disease (AD) pathogenesis involves critical phosphorylated tau (p-tau) abnormalities. This research employed bibliometric methods to systematically evaluate worldwide scientific trends, emerging foci, and international collaboration patterns regarding p-tau in AD research.
Methods: Relevant publications spanning 1991-2024 from the Web of Science Core Collection were extracted. Bibliometric analysis was performed using R package "Bibliometrix" (v4.3.3), CiteSpace (v6.1.R2) and VOSviewer (v1.6.20).
Results: A total of 2,685 publications were included. China led in publication volume (612, 22.8%), followed by the USA (586, 21.8%) and Sweden (212, 7.9%). University of London was the most productive institution (603 publications). Blennow Kaj stood out with publications and citations of 270 and 18,093. The Journal of Alzheimer's Disease and Neurology were the top-ranked journal, with the highest publications (321) and citations (6,446), respectively. Cluster analysis revealed four major clusters, including mechanisms underlying p-tau in AD, p-tau as biomarker in AD, diagnosis of AD using p-tau, and consensus in AD. Keyword burst analysis emphasized recent terms such as "neurofilament light," "dysfunction," "performance," and "biomarker."
Conclusion: This study systematically analyzed the researches on p-tau in AD. Research hotspots have evolved from the early focus on pathological features to the exploration of biomarkers-based diagnosis. Recently, the comprehensive assessment AD is emphasized, suggesting that future studies should pay more attention to regulatory mechanism of abnormal p-tau for identification of therapeutic targets and overcome the challenges of p-tau as biomarkers during clinical diagnosis.
作为全球痴呆负担的主要贡献者，阿尔茨海默病（AD）的发病机制涉及关键的磷酸化tau （p-tau）异常。本研究采用文献计量学方法系统评估AD研究中p-tau蛋白的全球科学趋势、新兴焦点和国际合作模式。方法：提取Web of Science核心馆藏1991-2024年的相关出版物。使用R软件包“Bibliometrix”（v4.3.3）、CiteSpace （v6.1.R2）和VOSviewer （v1.6.20）进行文献计量学分析。结果：共纳入2685篇文献。中国发表论文数量最多（612篇，22.8%），其次是美国（586篇，21.8%）和瑞典（212篇，7.9%）。伦敦大学是最多产的机构（603篇论文）。Blennow Kaj以270篇论文和18093篇引文脱颖而出。《阿尔茨海默病与神经病学杂志》（Journal of Alzheimer's Disease and Neurology）是排名最高的期刊，分别拥有最高的出版物（321篇）和引用（6446篇）。聚类分析揭示了四个主要的聚类，包括p-tau在AD中的潜在机制，p-tau作为AD的生物标志物，使用p-tau诊断AD，以及AD的共识。关键词爆发分析强调了“神经丝光”、“功能障碍”、“性能”和“生物标志物”等近期术语。结论：本研究系统分析了AD中p-tau蛋白的相关研究。研究热点从早期对病理特征的关注发展到对基于生物标志物的诊断的探索。近年来，AD的综合评价受到重视，提示未来的研究应更多地关注异常p-tau的调控机制，以确定治疗靶点，并克服p-tau作为生物标志物在临床诊断中的挑战。
期刊介绍：
As a unique forum devoted exclusively to the study of cognitive dysfunction, ''Dementia and Geriatric Cognitive Disorders'' concentrates on Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field.
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