Characteristics of Pathogens of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Hospitalized Patients: A Retrospective Study From 2010 to 2020.

IF 1.9 Q3 RESPIRATORY SYSTEM

Pulmonary Medicine Pub Date : 2025-11-11 eCollection Date: 2025-01-01 DOI:10.1155/pm/4025205

Songsong Yu, Tiecheng Yang

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Abstract

Aim: The aim of the study is to evaluate the distribution and drug resistance of infectious pathogens in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

Methods: This is a retrospective study of AECOPD patients who underwent pathogen evaluation and drug susceptibility tests.

Results: A total of 199 hospitalized AECOPD patients were analyzed. Among them, 77.9% had monoinfection, and 22.1% had multiple infections. Two hundred and eighty-eight strains were isolated, with 61.1% gram-negative, 3.8% gram-positive, and 35.0% fungi, while 58 strains were colonized. Common bacteria included Haemophilus parainfluenzae, Acinetobacter baumannii, and Pseudomonas aeruginosa. Staphylococcus aureus and Enterococcus faecalis were the main gram-positive cocci, and Pseudohyphae were the main fungi. Fifty gram-negative strains showed drug resistance (19 colonized strains), with high resistance to ceftriaxone in A. baumannii, P. aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Methicillin-resistant S. aureus was resistant to penicillin but sensitive to other antibiotics.

Conclusion: The study highlights the distribution of pathogens and the prevalence of drug-resistant strains among AECOPD patients.

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慢性阻塞性肺疾病住院患者急性加重病原菌特征：2010 - 2020年回顾性研究

目的：探讨慢性阻塞性肺疾病（AECOPD）急性加重期住院患者感染性病原体的分布及耐药情况。方法：对AECOPD患者进行病原菌鉴定和药敏试验的回顾性研究。结果：对199例AECOPD住院患者进行分析。其中单次感染占77.9%，多次感染占22.1%。分离菌株288株，其中革兰氏阴性菌61.1%，革兰氏阳性菌3.8%，真菌35.0%，定植菌58株。常见的细菌包括副流感嗜血杆菌、鲍曼不动杆菌和铜绿假单胞菌。革兰氏阳性球菌以金黄色葡萄球菌和粪肠球菌为主，真菌以假菌丝为主。50株革兰氏阴性菌株（19株定植）出现耐药，其中鲍曼假单胞菌、铜绿假单胞菌、肺炎克雷伯菌和大肠埃希菌对头孢曲松具有高耐药性。耐甲氧西林金黄色葡萄球菌对青霉素耐药，但对其他抗生素敏感。结论：本研究突出了AECOPD患者的病原菌分布和耐药菌株的流行情况。

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