The Effect of Gadolinium on Synthetic Magnetic Resonance Quantitative Imaging

IF 2.5 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging Pub Date : 2025-11-17 DOI:10.1111/jon.70104

Lenka Novakova, Igal Rosenstein, Markus Axelsson, Russell Ouellette

{"title":"The Effect of Gadolinium on Synthetic Magnetic Resonance Quantitative Imaging","authors":"Lenka Novakova, Igal Rosenstein, Markus Axelsson, Russell Ouellette","doi":"10.1111/jon.70104","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background and Purpose</h3>\n \n <p>Synthetic (Sy) MRI is a clinically approved technique providing quantitative MRI measures based on T<sub>1</sub>-weighted, T<sub>2</sub>-weighted, and proton density relaxometry. MRI sequences are often acquired after contrast injection with gadolinium (Gd) to assess active lesions in persons with multiple sclerosis (PwMS), affecting relaxation time. We aimed to assess the influence of Gd on the SyMRI-based volumetrics in PwMS.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We enrolled 106 PwMS and 15 controls who performed pre-/post-contrast brain SyMRI on a 3T scanner. We evaluated mean change in brain parenchymal fraction (BPF), white matter (WM), grey matter (GM), myelin (Myl), non-aqueous component (NAC), excess parenchymal water (EPW), and T<sub>1</sub> enhancement (T<sub>1</sub>E) using paired sample <i>t</i>-test for pre-/post-Gd volumes and independent sample <i>t</i>-test for comparison between groups.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The mean age was 40.9 and 39.9 years with 69% and 87% females in MS and controls, respectively. Compared to native volumetrics, Gd caused a significant observed volume increase (<i>p</i> < 0.001) in BPF 1.05 ± 0.3%, WM 2.8 ± 0.99%, Myl 1.42 ± 0.39%, NAC 1.04 ± 0.23%, and EPW 0.6 ± 0.4% and decrease in GM −3.05 ± 1.34% in MS. Similar change was seen in controls: BPF 0.99 ± 0.21%, WM 2.94 ± 0.93%, Myl 1.35 ± 0.37%, NAC 0.99 ± 0.22%, EPW 0.47 ± 0.29%, and GM −2.89 ± 1.18%. The change in T<sub>1</sub>E was 0.05 ± 0.12% in MS (<i>p</i> < 0.001) and 0.02 ± 0.25% (<i>p</i> = 0.76) in controls. The number of contrast-enhancing lesions correlated with T<sub>1</sub>E (<i>r</i> = 0.348, <i>p</i> < 0.003).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>There was a consistent pattern of volume changes in PwMS and controls, except for T<sub>1</sub>E, where the contrast could have affected the results in PwMS. Therefore, combining pre- and post-contrast metrics in longitudinal studies should be interpreted with caution.</p>\n </section>\n </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 6","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12623708/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neuroimaging","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jon.70104","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background and Purpose

Synthetic (Sy) MRI is a clinically approved technique providing quantitative MRI measures based on T₁-weighted, T₂-weighted, and proton density relaxometry. MRI sequences are often acquired after contrast injection with gadolinium (Gd) to assess active lesions in persons with multiple sclerosis (PwMS), affecting relaxation time. We aimed to assess the influence of Gd on the SyMRI-based volumetrics in PwMS.

Methods

We enrolled 106 PwMS and 15 controls who performed pre-/post-contrast brain SyMRI on a 3T scanner. We evaluated mean change in brain parenchymal fraction (BPF), white matter (WM), grey matter (GM), myelin (Myl), non-aqueous component (NAC), excess parenchymal water (EPW), and T₁ enhancement (T₁E) using paired sample t-test for pre-/post-Gd volumes and independent sample t-test for comparison between groups.

Results

The mean age was 40.9 and 39.9 years with 69% and 87% females in MS and controls, respectively. Compared to native volumetrics, Gd caused a significant observed volume increase (p < 0.001) in BPF 1.05 ± 0.3%, WM 2.8 ± 0.99%, Myl 1.42 ± 0.39%, NAC 1.04 ± 0.23%, and EPW 0.6 ± 0.4% and decrease in GM −3.05 ± 1.34% in MS. Similar change was seen in controls: BPF 0.99 ± 0.21%, WM 2.94 ± 0.93%, Myl 1.35 ± 0.37%, NAC 0.99 ± 0.22%, EPW 0.47 ± 0.29%, and GM −2.89 ± 1.18%. The change in T₁E was 0.05 ± 0.12% in MS (p < 0.001) and 0.02 ± 0.25% (p = 0.76) in controls. The number of contrast-enhancing lesions correlated with T₁E (r = 0.348, p < 0.003).

Conclusion

There was a consistent pattern of volume changes in PwMS and controls, except for T₁E, where the contrast could have affected the results in PwMS. Therefore, combining pre- and post-contrast metrics in longitudinal studies should be interpreted with caution.

Abstract Image

查看原文本刊更多论文

钆对合成磁共振定量成像的影响。

背景和目的：合成（Sy） MRI是一种临床批准的技术，提供基于t1加权、t2加权和质子密度弛豫测量的定量MRI测量。MRI序列通常是在注射造影剂钆（Gd）后获得的，以评估多发性硬化症（PwMS）患者的活动性病变，影响放松时间。我们的目的是评估Gd对PwMS中基于symri的体积指标的影响。方法：我们招募了106名PwMS患者和15名对照患者，他们在3T扫描仪上进行了对比前/对比后的脑SyMRI。我们对脑实质分数（BPF）、白质（WM）、灰质（GM）、髓磷脂（Myl）、非水成分（NAC）、过量实质水（EPW）和T1增强（T1E）的平均变化进行了评估，使用配对样本t检验进行gd前后体积比较，使用独立样本t检验进行组间比较。结果：MS患者的平均年龄为40.9岁，女性占69%，对照组为87%。与天然容积法相比，Gd引起了显著的体积增加（p1e为0.05±0.12%）(p1e （r = 0.348, p）。结论：除了T1E外，PwMS和对照组的体积变化模式一致，对比度可能影响PwMS的结果。因此，在纵向研究中结合对比前后的指标应谨慎解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!