{"title":"Rapid Progression of Cutaneous Large B-Cell Lymphoma During Hyperbaric Oxygen Therapy: A Case Report.","authors":"Matthew Kelly, Emily T Jones, Dag Shapshak","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We present a case of a patient with a history of chronic lymphocytic leukemia (CLL) and cutaneous B-cell lymphoma of the right leg. She had previously received radiation treatment to the affected area and subsequently developed radiation fibrosis with two non-healing ulcerations at the previous tumor sites. A biopsy revealed spongiotic and sparse superficial perivascular dermatitis. Due to poor wound healing, adjunctive hyperbaric oxygen (HBO₂) therapy was initiated. However, shortly after beginning HBO₂ treatments, the wounds worsened. Repeat biopsies were performed, and the new areas were consistent with cutaneous large B-cell lymphoma. Consequently, HBO₂ therapy was discontinued, and aggressive chemotherapy/immunotherapy was initiated. We recommend that patients with a history of cutaneous B-cell lymphoma be closely monitored for signs of tumor recurrence or disease worsening if they are to undergo adjunctive hyperbaric oxygen therapy.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"357-360"},"PeriodicalIF":0.6000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Undersea and Hyperbaric Medicine","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MARINE & FRESHWATER BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
We present a case of a patient with a history of chronic lymphocytic leukemia (CLL) and cutaneous B-cell lymphoma of the right leg. She had previously received radiation treatment to the affected area and subsequently developed radiation fibrosis with two non-healing ulcerations at the previous tumor sites. A biopsy revealed spongiotic and sparse superficial perivascular dermatitis. Due to poor wound healing, adjunctive hyperbaric oxygen (HBO₂) therapy was initiated. However, shortly after beginning HBO₂ treatments, the wounds worsened. Repeat biopsies were performed, and the new areas were consistent with cutaneous large B-cell lymphoma. Consequently, HBO₂ therapy was discontinued, and aggressive chemotherapy/immunotherapy was initiated. We recommend that patients with a history of cutaneous B-cell lymphoma be closely monitored for signs of tumor recurrence or disease worsening if they are to undergo adjunctive hyperbaric oxygen therapy.
期刊介绍：
Undersea and Hyperbaric Medicine Journal accepts manuscripts for publication that are related to the areas of diving
research and physiology, hyperbaric medicine and oxygen therapy, submarine medicine, naval medicine and clinical research
related to the above topics. To be considered for UHM scientific papers must deal with significant and new research in an
area related to biological, physical and clinical phenomena related to the above environments.
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