Circadian rest-activity rhythms and physical function in community-dwelling older men: The MrOS sleep study

IF 4.8 2区医学 Q2 CLINICAL NEUROLOGY

Sleep Health Pub Date : 2026-02-01 Epub Date: 2025-11-11 DOI:10.1016/j.sleh.2025.10.005

Yujia (Susanna) Qiao PhD , Terri Blackwell MA , Dorothy M. Chen MPH , Jamie M. Zeitzer PhD , Sonia Ancoli-Israel PhD , Alexander B. Posner MPH , Susan Redline MD, MPH , Gregory J. Tranah PhD , Kristine Yaffe MD , Katie L. Stone PhD , on behalf of the Osteoporotic Fractures in Men (MrOS) Study Group

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引用次数: 0

Abstract

Objectives

Circadian rest-activity rhythms (RARs) reflect ones' physical activity and sleep patterns over the 24-hour day, correlating with cardiometabolic risk, fall risk, and cognitive decline. Physical function also declines with advancing age, leading to disability and increased risk of mortality. Thus, we examined the associations between rest-activity rhythms and physical function in older men.

Methods

In the Osteoporotic Fractures in Men (MrOS) study, 2924 men (age = 76.3 ± 5.5 years old, 90% white) completed the sleep ancillary study (baseline) with valid wrist-worn accelerometry data and physical function measures. Physical function measures included the following: 6-meter gait speed, chair stand speed, and grip strength, assessed at baseline and up to 4 follow-up visits over 6.4 ± 3.9 years. Using 3 approaches to quantify rest-activity rhythms (functional principal components analysis, parametric, and non-parametric approaches), we evaluated cross-sectional and longitudinal associations between baseline rest-activity rhythm patterns and decline in physical function using mixed-effects models, adjusting for demographic, lifestyle, and medical covariates.

Results

Less strength of rest-activity rhythm (ie, principal component 1, amplitude, and relative amplitude) and lower regularity (pseudo-F statistic) were both cross-sectionally and longitudinally associated with poorer physical function, particularly with gait speed and chair stand speed. Yet, significant associations between timing-related rest-activity rhythm exposures and chair stand speed were only observed cross-sectionally. Overall, the magnitude of associations differed slightly across rest-activity rhythm estimation approaches and more substantially by physical function measures.

Conclusions

Rest-activity rhythms might be a potential risk modifiable factor to target for intervention in future studies if aiming to maintain better physical function, particularly lower extremity function.

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居住在社区的老年男性的昼夜休息-活动节律和身体功能：磁共振睡眠研究。

目的：昼夜休息-活动节律（RARs）反映了一个人在24小时内的身体活动和睡眠模式，与心脏代谢风险、跌倒风险和认知能力下降相关。身体机能也会随着年龄的增长而下降，从而导致残疾和死亡风险的增加。因此，我们研究了老年男性休息-活动节律与身体功能之间的关系。方法：在男性骨质疏松性骨折（MrOS）研究中，2924名男性（年龄= 76.3±5.5岁，90%为白人）通过有效的腕带加速度计数据和身体功能测量完成了睡眠辅助研究（基线）。身体功能测量包括：6米步态速度、椅子站立速度和握力，在基线和4次随访（6.4±3.9年）时进行评估。使用3种方法来量化休息-活动节律（功能主成分分析、参数和非参数方法），我们使用混合效应模型评估了基线休息-活动节律模式与身体功能下降之间的横断面和纵向关联，调整了人口统计学、生活方式和医学协变量。结果：静息-活动节律强度（即主成分1、振幅和相对振幅）和规律性（伪f统计量）较低在横断面和纵向上都与较差的身体功能相关，尤其是与步态速度和站立速度相关。然而，时间相关的休息-活动节奏暴露与椅子站立速度之间的显著关联仅在横断面上观察到。总的来说，休息-活动节律估计方法之间的关联程度略有不同，而身体功能测量方法之间的关联程度更大。结论：静息-活动节律可能是未来研究中干预的潜在危险因素，如果目标是保持更好的身体功能，特别是下肢功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Health CLINICAL NEUROLOGY-

CiteScore

6.30

自引率

9.80%

发文量

114

审稿时长

54 days

期刊介绍： Sleep Health Journal of the National Sleep Foundation is a multidisciplinary journal that explores sleep''s role in population health and elucidates the social science perspective on sleep and health. Aligned with the National Sleep Foundation''s global authoritative, evidence-based voice for sleep health, the journal serves as the foremost publication for manuscripts that advance the sleep health of all members of society.The scope of the journal extends across diverse sleep-related fields, including anthropology, education, health services research, human development, international health, law, mental health, nursing, nutrition, psychology, public health, public policy, fatigue management, transportation, social work, and sociology. The journal welcomes original research articles, review articles, brief reports, special articles, letters to the editor, editorials, and commentaries.