Therapeutic potential of natural compounds in the management of chronic diseases: Targeting PINK1–Parkin pathway

IF 3.7 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2026-01-01 Epub Date: 2025-11-07 DOI:10.1016/j.prp.2025.156284

Naglaa F. Khedr , Hend M. Selim , Gamal A. Abourayya

{"title":"Therapeutic potential of natural compounds in the management of chronic diseases: Targeting PINK1–Parkin pathway","authors":"Naglaa F. Khedr , Hend M. Selim , Gamal A. Abourayya","doi":"10.1016/j.prp.2025.156284","DOIUrl":null,"url":null,"abstract":"<div><div>Chronic diseases like neurodegenerative disorders, musculoskeletal issues, metabolic diseases, cancer, liver and kidney disorders are increasingly linked to mitochondrial dysfunction. PINK1-Parkin-mediated mitophagy, a vital autophagic process, plays a central role in maintaining cellular homeostasis by selectively eliminating damaged mitochondria, which is crucial for preserving mitochondrial integrity and preventing reactive oxygen species accumulation. Activation of the PINK1-Parkin signaling pathway has emerged as a promising therapeutic strategy to restore mitochondrial function and attenuate disease progression. Recent studies have demonstrated that natural PINK1-Parkin activators offer significant therapeutic potential for treating a wide range of chronic diseases by modulating mitochondrial dynamics, alleviating cellular inflammation, and preventing mitochondrial damage. This review provides an in-depth analysis of the molecular mechanisms underlying PINK1-Parkin signaling, discusses the therapeutic benefits of natural activators, and presents them as a compelling strategy for addressing mitochondrial dysfunction and mitigating the progression of chronic diseases.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"277 ","pages":"Article 156284"},"PeriodicalIF":3.7000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathology, research and practice","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0344033825004777","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/7 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Chronic diseases like neurodegenerative disorders, musculoskeletal issues, metabolic diseases, cancer, liver and kidney disorders are increasingly linked to mitochondrial dysfunction. PINK1-Parkin-mediated mitophagy, a vital autophagic process, plays a central role in maintaining cellular homeostasis by selectively eliminating damaged mitochondria, which is crucial for preserving mitochondrial integrity and preventing reactive oxygen species accumulation. Activation of the PINK1-Parkin signaling pathway has emerged as a promising therapeutic strategy to restore mitochondrial function and attenuate disease progression. Recent studies have demonstrated that natural PINK1-Parkin activators offer significant therapeutic potential for treating a wide range of chronic diseases by modulating mitochondrial dynamics, alleviating cellular inflammation, and preventing mitochondrial damage. This review provides an in-depth analysis of the molecular mechanisms underlying PINK1-Parkin signaling, discusses the therapeutic benefits of natural activators, and presents them as a compelling strategy for addressing mitochondrial dysfunction and mitigating the progression of chronic diseases.

查看原文本刊更多论文

天然化合物在慢性疾病管理中的治疗潜力：靶向PINK1-Parkin通路

神经退行性疾病、肌肉骨骼问题、代谢疾病、癌症、肝脏和肾脏疾病等慢性疾病越来越多地与线粒体功能障碍联系在一起。pink1 - parkin介导的线粒体自噬是一个重要的自噬过程，它通过选择性地消除受损的线粒体，在维持细胞稳态中起着核心作用，这对于保持线粒体完整性和防止活性氧积累至关重要。激活PINK1-Parkin信号通路已成为恢复线粒体功能和减缓疾病进展的一种有前景的治疗策略。最近的研究表明，天然的PINK1-Parkin激活剂通过调节线粒体动力学、减轻细胞炎症和防止线粒体损伤，为治疗多种慢性疾病提供了显著的治疗潜力。这篇综述深入分析了PINK1-Parkin信号传导的分子机制，讨论了天然激活剂的治疗益处，并提出了它们作为解决线粒体功能障碍和缓解慢性疾病进展的有力策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.