Targeting GPX4-dependent ferroptosis by natural compounds in multiple sclerosis.

IF 1.6 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2026-08-01 Epub Date: 2025-11-13 DOI:10.1080/10286020.2025.2576660

Ning Zhou, Yi-Rong Dong, Jin-Rong Wang, Cai-Xia Zang, Jing-Wei Ma, Yang Yang, Qiu-Zhu Chen, Yue-Qi Jiang, Xing Yang, Shou-Peng Cao, Mei-Chuan Zhou, Sen-Xiang Zeng, Fang-Fang Li, Xiu-Qi Bao, Dan Zhang

引用次数: 0

Abstract

Multiple sclerosis (MS) is an autoimmune-mediated, heterogeneous, multifactorial central nervous system degenerative disease influenced by genetics and environment. Ferroptosis, an iron-dependent lipid peroxidation/reactive oxygen species-induced programmed cell death, exacerbates MS pathology. Glutathione peroxidase 4 (GPX4) regulates ferroptosis by clearing peroxides to sustain cells. Targeting GPX4-mediated ferroptosis, especially via safe, potent natural compounds, is a promising MS treatment. This review explores GPX4-dependent ferroptosis's role in MS progression and summarizes natural compounds for MS therapy.

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多发性硬化症中天然化合物靶向gpx4依赖性铁下垂。

多发性硬化症（MS）是一种受遗传和环境影响的自身免疫介导的、异质性的、多因素的中枢神经系统退行性疾病。铁坏死是一种铁依赖性脂质过氧化/活性氧诱导的程序性细胞死亡，它会加剧多发性硬化症的病理。谷胱甘肽过氧化物酶4 （GPX4）通过清除过氧化物来维持细胞。靶向gpx4介导的铁下垂，特别是通过安全、有效的天然化合物，是一种有希望的MS治疗方法。本文综述了gpx4依赖性铁下垂在MS进展中的作用，并总结了MS治疗的天然化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.