Variation in Thyroid Function Tests in Acute Scrub Typhus Infection.

IF 1.2

Indian Journal of Endocrinology and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-10-25 DOI:10.4103/ijem.ijem_28_25

Sai N Gogineni, Adlyne R Asirvatham, Vasireddy N Tara, Veeraraghava K Ramadesikan, Asha Ranjan, Shriraam Mahadevan

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引用次数: 0

Abstract

Introduction: Immunoassays used to measure thyroid function tests (TFTs) are prone to interference due to several factors that could potentially affect clinical decisions. With increased awareness and frequency of testing TFT, even 1% prevalence of assay interferences would possibly increase the occurrence of deranged TFT significantly. In this study, we report six cases of thyroid hormone assay interference in acute scrub typhus infection.

Methods: A prospective observational study was conducted in patients admitted with acute scrub typhus infection. TFT was done for some indication that showed discordance with clinical suspicion. Initial assay was performed by electrochemiluminescence immunoassay (ECLIA) using a Roche Cobas e411 analyzer, which was verified by Chemiluminescent Microparticle Immuno Assay (CMIA) with an ARCHITECT i1000SR analyzer.

Results: Initial TFT done by ECLIA showed elevated FT4 and FT3(FT4>> FT3) with a normal or low-normal TSH in all cases. Samples were re-analyzed in the CMIA platform within 24 hours, which showed normal TFT, raising the suspicion of assay interference. TFT performed by ECLIA 6 weeks after recovery was normal in all patients.

Conclusion: Assay interference with TFT should always be considered when there is a discrepancy between clinical suspicion and biochemical values. It is prudent to confirm abnormal values on another platform to avoid misdiagnosis and unwarranted therapeutic decisions.

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急性恙虫病感染甲状腺功能试验的变化。

导言：用于测量甲状腺功能测试（TFTs）的免疫分析容易受到干扰，因为几个因素可能会影响临床决策。随着检测TFT的意识和频率的提高，即使1%的检测干扰也可能显著增加紊乱性TFT的发生。在本研究中，我们报告6例甲状腺激素检测干扰急性恙虫病感染。方法：对急性恙虫病患者进行前瞻性观察研究。对一些与临床怀疑不一致的指征进行了TFT。初始分析采用罗氏Cobas e411分析仪进行电化学发光免疫分析法（ECLIA），并用ARCHITECT i1000SR分析仪进行化学发光微粒免疫分析法（CMIA）验证。结果：ECLIA初始TFT显示FT4和FT3升高（FT4>> FT3）， TSH正常或低正常。24小时内在CMIA平台上重新分析样品，TFT显示正常，引起检测干扰的怀疑。所有患者恢复后6周ECLIA行TFT均正常。结论：当临床怀疑与生化值存在差异时，应考虑TFT检测干扰。在另一个平台上确认异常值是谨慎的，以避免误诊和不合理的治疗决定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The Indian Journal of Endocrinology and Metabolism (IJEM) aims to function as the global face of Indian endocrinology research. It aims to act as a bridge between global and national advances in this field. The journal publishes thought-provoking editorials, comprehensive reviews, cutting-edge original research, focused brief communications and insightful letters to editor. The journal encourages authors to submit articles addressing aspects of science related to Endocrinology and Metabolism in particular Diabetology. Articles related to Clinical and Tropical endocrinology are especially encouraged. Sub-topic based Supplements are published regularly. This allows the journal to highlight issues relevant to Endocrine practitioners working in India as well as other countries. IJEM is free access in the true sense of the word, (it charges neither authors nor readers) and this enhances its global appeal.