In vitro anti-diabetic activities of phytochemicals isolated from Cornus officinalis fruits

IF 2.9 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-11-10 DOI:10.1016/j.fitote.2025.106984

Zhi-you Hao , Xiao-lan Wang , Meng Yang , Shi-qi Zhou , Chao-yuan Xiao , Jun-yang Zhang , Shuang-shuang Xie , Meng Li , Yan-gang Cao , Yan-jun Sun , Xiao-ke Zheng , Wei-sheng Feng

{"title":"In vitro anti-diabetic activities of phytochemicals isolated from Cornus officinalis fruits","authors":"Zhi-you Hao , Xiao-lan Wang , Meng Yang , Shi-qi Zhou , Chao-yuan Xiao , Jun-yang Zhang , Shuang-shuang Xie , Meng Li , Yan-gang Cao , Yan-jun Sun , Xiao-ke Zheng , Wei-sheng Feng","doi":"10.1016/j.fitote.2025.106984","DOIUrl":null,"url":null,"abstract":"<div><div>Four previously undescribed compounds, including two dihydroisocoumarin glycosides (1 and 2), a truxillic acid derivative (4), and a cadinane-type sesquiterpene (5), were isolated from the fruits of Cornus officinalis Sieb. et Zucc., along with seven known ones (3, 6–11). Their chemical structures were determined by extensive spectroscopic methods and computational analyses. All isolated compounds were evaluated for the effects on glucose consumption in insulin-resistant (IR) HepG2 cells. The compounds exhibited no significant cytotoxicity at 10.0 μM in the CCK-8 assay. Compounds 2, 3, and 8 significantly increased glucose consumption (P < 0.05) at 5.0 and 10.0 μM. The 2-NBDG labeling indicated that compounds 2 and 8 significantly increased glucose uptake at 10 μM. Moreover, compounds 2 and 8 also significantly increased insulin receptor (INSR) expression, indicating their potential to upregulate the INSR in the cytomembrane and enhance glucose uptake.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"188 ","pages":"Article 106984"},"PeriodicalIF":2.9000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X25006100","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Four previously undescribed compounds, including two dihydroisocoumarin glycosides (1 and 2), a truxillic acid derivative (4), and a cadinane-type sesquiterpene (5), were isolated from the fruits of Cornus officinalis Sieb. et Zucc., along with seven known ones (3, 6–11). Their chemical structures were determined by extensive spectroscopic methods and computational analyses. All isolated compounds were evaluated for the effects on glucose consumption in insulin-resistant (IR) HepG2 cells. The compounds exhibited no significant cytotoxicity at 10.0 μM in the CCK-8 assay. Compounds 2, 3, and 8 significantly increased glucose consumption (P < 0.05) at 5.0 and 10.0 μM. The 2-NBDG labeling indicated that compounds 2 and 8 significantly increased glucose uptake at 10 μM. Moreover, compounds 2 and 8 also significantly increased insulin receptor (INSR) expression, indicating their potential to upregulate the INSR in the cytomembrane and enhance glucose uptake.

Abstract Image

查看原文本刊更多论文

山茱萸果实植物化学物质体外抗糖尿病活性研究。

从山茱萸（Cornus officinalis Sieb）的果实中分离出四种先前未描述的化合物，包括两种二氢异香豆素苷（1和2），一种松木酸衍生物(4)和一种cadinine型倍半萜(5)。调查。，以及七个已知的（3,6 -11）。通过广泛的光谱方法和计算分析确定了它们的化学结构。所有分离的化合物都被评估对胰岛素抵抗（IR） HepG2细胞葡萄糖消耗的影响。CCK-8实验显示，在10.0 μM下，化合物没有明显的细胞毒性。化合物2、3和8显著增加葡萄糖消耗(P

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.

文献相关原料

原料信息

原料厂家

CCK-8