Higher charlson comorbidity index is associated with increased risk of erectile dysfunction: evidence from NHANES data.

IF 3 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2025-12-11 Epub Date: 2025-11-12 DOI:10.1080/13685538.2025.2581661

Xiaobao Chen, Junwei Lin, Binhong Liu, Lingjun Liu, Wei Jiang, Ruoyun Xie

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引用次数: 0

Abstract

Background: The Charlson Comorbidity Index (CCI) quantifies multimorbidity, but its link to erectile dysfunction (ED) remains underexplored.

Methods: Using data from the National Health and Nutrition Examination Survey (NHANES), our study investigated the association between CCI and ED. Our analysis involved weighted multivariate regression, subgroup analyses, restricted cubic spline (RCS) analyses, and propensity score matching (PSM) analyses.

Results: Among the 2295 adults included in this study, 863 (37.6%) were diagnosed with ED. Weighted multivariate regression analyses revealed a significant positive association between the CCI and the risk of ED. Each additional point on the CCI was associated with a 32% higher risk of ED (OR 1.32, 95% CI 1.18-1.47). Furthermore, when participants were categorized into two groups based on CCI scores (CCI = 0 and CCI ≥ 1), the risk of ED was notably higher for those with CCI ≥ 1, showing a 122% increased risk compared to those with CCI = 0 (OR 2.22, 95% CI 1.62-3.05). Sensitivity analyses, including subgroup analyses and PSM, consistently supported the strong positive correlation between the CCI and ED.

Conclusion: Our study indicates that a higher CCI is positively correlated with an increased risk of ED, suggesting that lower CCI scores are associated with lower risk of ED.

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较高的charlson合并症指数与勃起功能障碍风险增加相关：来自NHANES数据的证据。

背景：Charlson共病指数（CCI）量化了多病，但其与勃起功能障碍（ED）的关系仍未得到充分探讨。方法：利用美国国家健康与营养调查（NHANES）的数据，研究CCI与ED之间的关系。我们的分析包括加权多元回归、亚组分析、限制性三次样条（RCS）分析和倾向评分匹配（PSM）分析。结果：在本研究纳入的2295名成年人中，863名（37.6%）被诊断为ED。加权多变量回归分析显示CCI与ED风险之间存在显著正相关。CCI每增加一点，ED风险增加32% （OR 1.32, 95% CI 1.18-1.47）。此外，当参与者根据CCI评分（CCI = 0和CCI≥1）分为两组时，CCI≥1的患者发生ED的风险明显更高，与CCI = 0的患者相比，风险增加了122% （OR 2.22, 95% CI 1.62-3.05）。包括亚组分析和PSM在内的敏感性分析一致支持CCI与ED之间的强正相关。结论：我们的研究表明，较高的CCI与ED风险增加正相关，表明较低的CCI评分与较低的ED风险相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.