Clinical efficacy of Guishao Shengxue decoction in the treatment of pediatric immune thrombocytopenia: A randomized controlled trial

IF 2.4 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing Pub Date : 2025-11-01 DOI:10.1016/j.explore.2025.103277

Wei Wang , Xiaofei Xie , Shengtao Cui , Lin Xue

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引用次数: 0

Abstract

Background

Current treatments for pediatric immune thrombocytopenia (ITP) are effective but often associated with significant side effects, highlighting the need for safer and more sustainable alternatives. The objective of this study is to evaluate the clinical efficacy and safety of Guishao Shengxue Decoction (GSD) as a complementary therapy for ITP, aiming to provide a safer and more sustainable alternative to conventional treatments.

Methods

In this randomized, double-blind study, 42 children with persistent or chronic ITP were enrolled and allocated equally to treatment or control groups. The treatment group received GSD combined with conventional therapy, while the control group received a placebo combined with conventional therapy for six months. Efficacy outcomes included platelet parameters, immune and hematological markers, and safety evaluations.

Results

The treatment group demonstrated higher complete response (33.33% vs. 14.29%), overall response rate (95.24% vs. 71.43%), and durable response (95.24% vs. 80.95%) compared to the control group. Platelet indices and hematological parameters improved significantly in the treatment group, along with reduced platelet-associated immunoglobulins and better immune modulation.

Conclusions

GSD enhances clinical outcomes, supports platelet recovery, and modulates immune function in pediatric ITP, offering a safe and effective adjunct to conventional therapy.

查看原文本刊更多论文

桂芍生血汤治疗小儿免疫性血小板减少症的临床疗效：随机对照试验。

背景：目前儿童免疫性血小板减少症（ITP）的治疗是有效的，但往往伴有显著的副作用，这突出了对更安全、更可持续的替代方案的需求。本研究旨在评价桂芍生血汤（GSD）作为ITP补充治疗的临床疗效和安全性，以期提供一种更安全、更可持续的替代常规治疗方法。方法：在这项随机双盲研究中，42名患有持续性或慢性ITP的儿童被纳入研究，并被平均分配到治疗组和对照组。治疗组采用GSD联合常规治疗，对照组采用安慰剂联合常规治疗，疗程6个月。疗效指标包括血小板参数、免疫和血液学指标以及安全性评价。结果：治疗组完全缓解率（33.33% vs. 14.29%）、总缓解率（95.24% vs. 71.43%）、持续缓解率（95.24% vs. 80.95%）均高于对照组。治疗组血小板指数和血液学参数明显改善，血小板相关免疫球蛋白降低，免疫调节改善。结论：GSD可改善儿童ITP的临床结果，支持血小板恢复，调节免疫功能，为常规治疗提供安全有效的辅助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Explore-The Journal of Science and Healing 医学-全科医学与补充医学

CiteScore

3.00

自引率

8.30%

发文量

179

审稿时长

25 days

期刊介绍： EXPLORE: The Journal of Science & Healing addresses the scientific principles behind, and applications of, evidence-based healing practices from a wide variety of sources, including conventional, alternative, and cross-cultural medicine. It is an interdisciplinary journal that explores the healing arts, consciousness, spirituality, eco-environmental issues, and basic science as all these fields relate to health.