Association of BDNF Val66Met genotype with obesity indicators and metabolic parameters.

IF 3.7 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

International Journal of Food Sciences and Nutrition Pub Date : 2025-12-01 Epub Date: 2025-11-12 DOI:10.1080/09637486.2025.2584321

Cansu Memiç İnan, Mustafa Çapraz, Akın Tekcan, Ayşe Özfer Özçelik

{"title":"Association of BDNF Val66Met genotype with obesity indicators and metabolic parameters.","authors":"Cansu Memiç İnan, Mustafa Çapraz, Akın Tekcan, Ayşe Özfer Özçelik","doi":"10.1080/09637486.2025.2584321","DOIUrl":null,"url":null,"abstract":"The aim of this study was to investigate the association of BDNF Val66Met genotype with obesity markers and metabolic parameters in a Turkish population. The study data were collected with a questionnaire form. The questionnaire form included general information, anthropometric measurements, dietary intake, lifestyle factors and biochemical parameters. Genotyping of the Val66Met variant in the BDNF gene was performed by real-time polymerase chain reaction (PCR). Individuals with the AG+AA genotype showed differences in obesity and metabolic parameters compared to GG homozygotes. Additionally, individuals with the AG+AA genotype showed lower waist circumference (pinteraction = 0.04), waist-to-hip ratio (pinteraction = 0.003), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR; pinteraction = 0.009) when consuming a high-fibre diet (>18 g/day) compared to GG homozygotes. The study highlights the influence of BDNF Val66Met genotype on obesity and metabolic parameters, with dietary fibre intake potentially modifying these effects.","PeriodicalId":14087,"journal":{"name":"International Journal of Food Sciences and Nutrition","volume":" ","pages":"910-919"},"PeriodicalIF":3.7000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Food Sciences and Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1080/09637486.2025.2584321","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/12 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The aim of this study was to investigate the association of BDNF Val66Met genotype with obesity markers and metabolic parameters in a Turkish population. The study data were collected with a questionnaire form. The questionnaire form included general information, anthropometric measurements, dietary intake, lifestyle factors and biochemical parameters. Genotyping of the Val66Met variant in the BDNF gene was performed by real-time polymerase chain reaction (PCR). Individuals with the AG+AA genotype showed differences in obesity and metabolic parameters compared to GG homozygotes. Additionally, individuals with the AG+AA genotype showed lower waist circumference (pinteraction = 0.04), waist-to-hip ratio (pinteraction = 0.003), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR; pinteraction = 0.009) when consuming a high-fibre diet (>18 g/day) compared to GG homozygotes. The study highlights the influence of BDNF Val66Met genotype on obesity and metabolic parameters, with dietary fibre intake potentially modifying these effects.

查看原文本刊更多论文

BDNF Val66Met基因型与肥胖指标和代谢参数的关系

本研究的目的是调查土耳其人群中BDNF Val66Met基因型与肥胖标志物和代谢参数的关系。研究数据以问卷形式收集。问卷形式包括一般信息、人体测量、饮食摄入、生活方式因素和生化参数。采用实时聚合酶链反应（real-time polymerase chain reaction， PCR）对BDNF基因Val66Met变异进行基因分型。与GG纯合子相比，AG+AA基因型个体在肥胖和代谢参数方面存在差异。此外，与GG纯合子相比，AG+AA基因型的个体在食用高纤维饮食（>18 g/天）时，腰围（p互作= 0.04）、腰臀比（p互作= 0.003）和胰岛素抵抗稳态模型评估（HOMA-IR； p互作= 0.009）更低。该研究强调了BDNF Val66Met基因型对肥胖和代谢参数的影响，而膳食纤维的摄入可能会改变这些影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Food Sciences and Nutrition 工程技术-食品科技

CiteScore

7.50

自引率

2.60%

发文量

审稿时长

1 months

期刊介绍： The primary aim of International Journal of Food Sciences and Nutrition is to integrate food science with nutrition. Improvement of knowledge in human nutrition should always be the final objective of submitted research. It''s an international, peer-reviewed journal which publishes high quality, original research contributions to scientific knowledge. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.