A 3D-printed PLA honeycomb-shaped scaffolds for bone tissue engineering.

IF 2.5 4区医学 Q3 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Applications Pub Date : 2026-05-01 Epub Date: 2025-11-10 DOI:10.1177/08853282251396800

Aochong Zhou, Junwei Liao, Zhishen Huang, Kaicheng Zeng, Yuying Guo, Xuedan Hou, Hongxia Zhao

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引用次数: 0

Abstract

Objectives: Polylactic acid (PLA) is widely used as biomedical material due to its good biocompatibility and biodegradability. A PLA honeycomb-shaped porous scaffold as bone graft substitute was printed by 3D-printed. Method:Coating and mineralization treatment was used in order to further improve the properties of the PLA scaffold. The materials were characterized by infrared spectroscopy (IR) and Xray diffraction (XRD). The structure of the scaffolds was observed by electric scanning microscope (SEM). The hydrophilicity of the material was observed by contact angle tester. Compression tests were carried out to evaluate the strength of the scaffolds. The biocompatibility of the scaffolds was evaluated by MTT. The behaviors and responses of preosteoblast cells on the scaffolds were studied as well. Results: The porosity of the 3D-printed PLA scaffold was 82.6%. The compressive strength and compressive modulus value of the PLA scaffolds was 8.22 ± 0.16 MPa and 244.3 ± 5.7 MPa, respectively. Coating and mineralization treatment could improved the hydrophilicity, strength and the biocompatibility of the scaffold. Conclusions: The 3D-printed PLA porous scaffold has a good prospect for application as artificial scaffold for bone tissue engineering.

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一种用于骨组织工程的3d打印PLA蜂窝状支架。

目的：聚乳酸（PLA）因其良好的生物相容性和生物降解性而被广泛用作生物医用材料。采用3d打印技术打印PLA蜂窝状多孔支架作为骨移植替代物。方法：采用涂层和矿化处理，进一步提高聚乳酸支架的性能。采用红外光谱（IR）和x射线衍射（XRD）对材料进行了表征。利用电子扫描显微镜观察支架的结构。用接触角仪观察了材料的亲水性。进行了压缩试验来评估支架的强度。MTT法评价支架的生物相容性。研究了成骨前细胞在支架上的行为和反应。结果：3d打印PLA支架的孔隙率为82.6%。PLA支架的抗压强度和抗压模量分别为8.22±0.16 MPa和244.3±5.7 MPa。涂层和矿化处理可以提高支架的亲水性、强度和生物相容性。结论：3d打印聚乳酸多孔支架作为骨组织工程人工支架具有良好的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.