Intensive Care Unit Stay and Mechanical Ventilation Among Adults with Respiratory Syncytial Virus-Related Hospitalization by Age and Comorbidity Status.

IF 5.3 3区医学 Q1 INFECTIOUS DISEASES

Infectious Diseases and Therapy Pub Date : 2026-01-01 Epub Date: 2025-11-11 DOI:10.1007/s40121-025-01255-7

Caihua Liang, Yun Zhou, Matthew Kent, Erica L Chilson, Bradford D Gessner, Elizabeth Begier

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Abstract

Introduction: Respiratory syncytial virus (RSV) can cause severe outcomes in hospitalized older adults and those with underlying comorbidities, but little is known regarding such outcomes stratified by age and comorbidity status. This study aimed to describe the intensive care unit (ICU) stay and receipt of mechanical ventilation (MV) among adults with RSV-related hospitalizations by age and risk group.

Methods: A retrospective cohort study was conducted using Optum Market Clarity Database to identify RSV-related hospitalizations among adults aged ≥ 18 years. ICU admission, length of ICU stays, and MV use were summarized by age and risk group. Patients with at least one predefined underlying condition were defined as high-risk, while low-risk adults lacked any of these conditions.

Results: A total of 13,734 RSV-related hospitalizations were identified, including 11,838 unique patients. Of these, 10.2% were low-risk and 89.8% were high-risk. ICU admissions occurred in 31.2% of RSV-related hospitalizations (high-risk, 32.1%; low-risk, 22.6%). High-risk younger adults had higher percentage of ICU admissions (18-49 years, 31.1%; 50-59 years, 34.8%) than older adults at low-risk (60-74 years, 27.8%; ≥ 75 years, 21.6%). Mean length of ICU stay was 4.5 days (high-risk, 4.6 days; low-risk, 2.8 days). Younger adults at high-risk had longer ICU stays (18-49 years, 5.9 days; 50-59 years, 5.4 days) compared to older adults at low-risk (60-74 years, 4.2 days; ≥ 75 years, 1.8 days). MV was used in 6.2% of RSV-related hospitalizations (high-risk, 6.6%; low-risk, 2.6%). ICU stays for those receiving MV were more than twice as long as ICU stays overall (mean 10.6 days).

Conclusions: During RSV-related hospitalizations, adults at high-risk experienced more critical care outcomes compared to low-risk adults. Within risk status, results were similar with increasing age. However, younger adults at high-risk had more severe outcomes compared to older adults without such comorbidities, highlighting the importance of disease prevention in this group.

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按年龄和合胞病毒相关住院的成人重症监护病房住院时间和机械通气情况

呼吸道合胞病毒（RSV）可在住院的老年人和有潜在合并症的老年人中引起严重的结果，但对按年龄和合并症分层的这种结果知之甚少。本研究旨在描述年龄和危险组中与呼吸道感染相关住院的成人重症监护病房（ICU）住院时间和机械通气（MV）接收情况。方法：使用Optum市场清晰度数据库进行回顾性队列研究，以确定年龄≥18岁的成年人中与rsv相关的住院情况。按年龄和危险组总结ICU入院、ICU住院时间和MV使用情况。至少有一种预先确定的潜在疾病的患者被定义为高风险，而低风险的成年人没有这些疾病。结果：共确定了13734例与rsv相关的住院病例，其中包括11838例独特患者。其中，10.2%为低危，89.8%为高危。与rsv相关的住院病例中，有31.2%入院ICU（高危32.1%，低危22.6%）。高危年轻人的ICU入院率（18-49岁，31.1%；50-59岁，34.8%）高于低危老年人（60-74岁，27.8%；≥75岁，21.6%）。平均ICU住院时间为4.5天（高危4.6天，低危2.8天）。与低风险的老年人（60-74岁，4.2天；≥75岁，1.8天）相比，高风险的年轻人在ICU的停留时间更长（18-49岁，5.9天；50-59岁，5.4天）。6.2%的rsv相关住院患者使用MV（高风险，6.6%；低风险，2.6%）。接受MV治疗的患者的ICU住院时间是总体ICU住院时间的两倍多（平均10.6天）。结论：在与rsv相关的住院期间，与低风险成人相比，高风险成人经历了更多的重症监护结果。在危险状态下，随着年龄的增长，结果相似。然而，与没有这些合并症的老年人相比，高危的年轻人有更严重的结果，这突出了这一群体预防疾病的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Diseases and Therapy Medicine-Microbiology (medical)

CiteScore

8.60

自引率

1.90%

发文量

136

审稿时长

6 weeks

期刊介绍： Infectious Diseases and Therapy is an international, open access, peer-reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of infectious disease therapies and interventions, including vaccines and devices. Studies relating to diagnostic products and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to, bacterial and fungal infections, viral infections (including HIV/AIDS and hepatitis), parasitological diseases, tuberculosis and other mycobacterial diseases, vaccinations and other interventions, and drug-resistance, chronic infections, epidemiology and tropical, emergent, pediatric, dermal and sexually-transmitted diseases.