Epidemiological and clinical characteristics associated with enterovirus D68 respiratory diseases in Asian children: a systematic review and meta-analysis

IF 3 4区医学 Q1 PEDIATRICS

Jornal de pediatria Pub Date : 2026-01-01 Epub Date: 2025-11-14 DOI:10.1016/j.jped.2025.101475

Xiaojing Lu , Bingbing Li , Shufang Li , Lihong Wang , Guangen Guo , Yanli Zhang , Jiajia Duan , Changlian Zhu

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引用次数: 0

Abstract

Objective

This study aimed to determine the epidemiology and clinical characteristics of EV-D68-associated respiratory diseases among Asian children.

Sources

The PubMed, Embase, Web of Science, Scopus, China National Knowledge Infrastructure (CNKI), VIP, WanFang, and SinoMed electronic databases were searched from inception to February 28, 2025, to identify relevant articles. Studies reporting the detection rate of enterovirus D68 (EV-D68) in pediatric patients with respiratory tract infections were included. The methodological quality regarding the risk of bias was assessed according to the approach proposed by the Joanna Briggs Institute.

Summary of the findings

Twenty studies involving 47,451 participants were included; additionally, 450 participants were positive for EV-D68 infection. The detection rate of EV-D68 ranged from 0.23 % to 10.56 %, with a pooled prevalence of 1.29 % (95 % CI 0.88–1.78 %), but significant heterogeneity (I² = 94.20 %, p < 0.001) indicated that this estimate was context-dependent. Subgroup analyses revealed that detection rates varied substantially by country, study period, and income level. Pneumonia is the most common respiratory disease presentation. EV-D68 is most prevalent during the summer and autumn.

Conclusion

This is the first review to focus specifically on Asian children, which suggests that EV-D68 detection rates vary significantly across Asian populations and are especially influenced by geographic location and surveillance timing. EV-D68 infection in children is most frequently associated with pneumonia. These findings support targeted regional surveillance networks during the summer-autumn seasons to improve clinical diagnostics and public health responses.

Trial Registration

PROSPERO Identifier: CRD42023449889.

查看原文本刊更多论文

亚洲儿童肠道病毒D68呼吸道疾病相关的流行病学和临床特征：一项系统综述和荟萃分析

目的：本研究旨在了解亚洲儿童ev - d68相关呼吸道疾病的流行病学和临床特征。资料来源：检索PubMed、Embase、Web of Science、Scopus、CNKI、VIP、万方、SinoMed等电子数据库，检索时间为创刊至2025年2月28日。研究报告了肠道病毒D68 （EV-D68）在儿科呼吸道感染患者中的检出率。根据乔安娜布里格斯研究所提出的方法评估偏倚风险的方法学质量。研究结果总结：纳入了20项研究，涉及47,451名参与者；此外，450名参与者的EV-D68感染呈阳性。的检出率EV-D68范围从0.23 % 10.56 %,汇集患病率为1.29 %(95 %可信区间0.88 - -1.78 %),但是显著的异质性(我²  % = 94.20,p 结论:这是第一个评论特别关注亚洲的孩子,这表明EV-D68亚洲人群检出率显著不同,尤其受地理位置的影响和监测时机。儿童感染EV-D68最常与肺炎相关。这些发现支持在夏秋季节建立有针对性的区域监测网络，以改进临床诊断和公共卫生反应。试验注册：PROSPERO标识符：CRD42023449889。

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来源期刊

Jornal de pediatria 医学-小儿科

CiteScore

5.60

自引率

3.00%

发文量

审稿时长

43 days

期刊介绍： Jornal de Pediatria is a bimonthly publication of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP). It has been published without interruption since 1934. Jornal de Pediatria publishes original articles and review articles covering various areas in the field of pediatrics. By publishing relevant scientific contributions, Jornal de Pediatria aims at improving the standards of pediatrics and of the healthcare provided for children and adolescents in general, as well to foster debate about health.