Chemistry and biological properties of Ascaridole: A systematic review

IF 2.9 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-11-08 DOI:10.1016/j.fitote.2025.106982

Andres Camilo Moreno Abadia, Simone Cristina Baggio Gnoatto

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Abstract

Ascaridole is an endoperoxide monoterpene with a distinctive peroxide bridge, predominantly sourced from Dysphania ambrosioides. This compound exhibits broad-spectrum biological activities including antiparasitic (antileishmanial, antimalarial, antitrypanosomal), anticancer, antimicrobial, and anti-inflammatory effects. Studies suggest that its mechanism of action involves ROS generation through peroxide group activation, which may induce oxidative stress and mitochondrial dysfunction via artemisinin-like pathways. Although its efficacy has been demonstrated in various experimental models, its therapeutic application faces limitations, mainly due to the scarcity of studies evaluating its activity as an isolated compound. Future investigations should prioritize rigorous preclinical and clinical studies using purified ascaridole to establish comprehensive safety profiles and validate its development as a therapeutic agent. This systematic review addresses the underexplored therapeutic potential of ascaridole by providing an integrated analysis of its chemical, phytochemical, and biological properties. The review synthesizes current knowledge, identifies existing research limitations, and outlines strategic perspectives for advancing ascaridole development as a novel therapeutic candidate.

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蛔虫素的化学和生物学特性：系统综述。

蛔虫素是一种内过氧化物单萜烯，具有独特的过氧化物桥，主要来源于苦参。该化合物具有广谱生物活性，包括抗寄生虫（抗利什曼原虫、抗疟疾、抗锥虫）、抗癌、抗菌和抗炎作用。研究认为其作用机制涉及通过过氧化基团激活产生ROS，通过类青蒿素途径诱导氧化应激和线粒体功能障碍。尽管其有效性已在各种实验模型中得到证明，但其治疗应用面临局限性，主要是由于缺乏评估其作为分离化合物活性的研究。未来的研究应优先考虑使用纯化蛔虫素进行严格的临床前和临床研究，以建立全面的安全性，并验证其作为治疗药物的发展。本系统综述通过对其化学、植物化学和生物学特性的综合分析，阐述了蛔虫素未被充分开发的治疗潜力。这篇综述综合了目前的知识，确定了现有的研究局限性，并概述了推进蛔虫素作为一种新型候选治疗药物发展的战略前景。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.