Amide alkaloids from Piper polysyphorum and their antifungal activities

IF 2.9 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-11-08 DOI:10.1016/j.fitote.2025.106981

Ling-Yan Liu , Fang Yue , Rui-Han Zhang , Ling Liu , Shan-Peng Xu , Chang Li , Yue-Hu Pei

引用次数: 0

Abstract

Eight new amide alkaloids, named piperpolyactam A (1) and piperpolyamide A-G (2–8), along with thirty known ones (9–38) were isolated from the extract of piper polysyphorum. Their structures were elucidated by extensive spectroscopic analyses (including 1D, 2D-NMR and HRESIMS). Compounds 1–38 were assessed for antifungal activity against Candida albicans CMCC 98001 and Aspergillus niger R330. Compound 36 showed a significant antifungal effect against A. niger R330, with the MIC value of 0.78 μg/mL.

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红椒酰胺类生物碱及其抗真菌活性研究。

从胡椒多参提取物中分离到8个新的酰胺类生物碱，分别命名为胡椒聚酰胺A(1)和胡椒聚酰胺A- g(2-8)，以及30个已知的酰胺类生物碱（9-38）。它们的结构通过广泛的光谱分析（包括1D， 2D-NMR和HRESIMS）得到了阐明。测定化合物1 ~ 38对白色念珠菌CMCC 98001和黑曲霉R330的抗真菌活性。化合物36对黑曲霉R330有显著的抑制作用，MIC值为0.78 μg/mL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.