Wen-Qi Zheng, José M Porcel, Y C Gary Lee, Zhi-De Hu
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引用次数: 0
Abstract
Pleural fluid biochemical analyses are of great value in verifying the etiology of undiagnosed pleural effusions. The preanalytical phase of pleural fluid biochemical analyses refers to the potential errors associated with specimen collection procedures, transportation, and sample stability. The analytical phase refers to the matrix effects and interference. The post-analytical phase refers to the clinical interpretation of the biochemical analyses. This review summarizes the preanalytical, analytical, and postanalytical phases of pleural fluid biochemical analyses. Evidence regarding potential preanalytical errors (e.g. stability, interference, and effects of anticoagulants on biomarker results) was summarized. In addition, we compiled evidence on the clinical interpretation of pleural fluid biomarkers, particularly from systematic reviews and meta-analyses. Finally, we discuss the future directions of biochemical analyses of pleural fluid.
期刊介绍：
Critical Reviews in Clinical Laboratory Sciences publishes comprehensive and high quality review articles in all areas of clinical laboratory science, including clinical biochemistry, hematology, microbiology, pathology, transfusion medicine, genetics, immunology and molecular diagnostics. The reviews critically evaluate the status of current issues in the selected areas, with a focus on clinical laboratory diagnostics and latest advances. The adjective “critical” implies a balanced synthesis of results and conclusions that are frequently contradictory and controversial.
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