Association of high-normal thyroid-stimulating hormone levels with metabolic syndrome and abdominal obesity in euthyroid adolescents: insights from the Korea National Health and Nutrition Examination Survey.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2025-10-01 Epub Date: 2025-10-31 DOI:10.6065/apem.2448324.162

Jung Heo, Hyunjyung Oh, Kyungdo Han, Min-Kyung Lee

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Abstract

Purpose: Metabolic syndrome (MetS) is increasingly prevalent among adolescents, and thyroid-stimulating hormone (TSH) levels influence metabolic health. This study investigates whether TSH levels are associated with MetS and its components in euthyroid adolescents.

Methods: We used data from the Korean National Health and Nutrition Examination Survey between 2013 and 2015. The study included 940 euthyroid adolescents aged 10-18 years, who were divided into 2 groups: high-normal TSH group (top 25% of euthyroid TSH levels) and nonhigh TSH group (remaining 75%). We analyzed the association between high-normal TSH levels and MetS and its components.

Results: TSH quartiles were related to MetS (P for trend=0.006). The prevalence of MetS was 3.5% in the high-normal TSH group and 1.9% in the nonhigh group (P=0.1929). Abdominal obesity was more prevalent in the high-normal TSH than in the nonhigh TSH group (16.2% vs. 9.6%, P=0.0153). Other MetS components were more prevalent in the high-normal TSH group, but the difference was not significant. High-normal TSH was significantly associated with abdominal obesity (adjusted odds ratio, 1.975; 95% confidence interval, 1.104-3.531, P=0.0218).

Conclusion: In euthyroid adolescents, a significant trend was observed between TSH quartile and MetS. Specifically, high-normal TSH levels showed a significant association with abdominal obesity, a key component of MetS.

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高正常促甲状腺激素水平与正常甲状腺青少年代谢综合征和腹部肥胖的关系：来自韩国国家健康和营养检查调查的见解

目的：代谢综合征（MetS）在青少年中越来越普遍，促甲状腺激素（TSH）水平影响代谢健康。本研究探讨了TSH水平是否与甲状腺功能正常的青少年的MetS及其成分有关。方法：采用2013 - 2015年韩国国家健康与营养检查调查数据。本研究纳入940名10-18岁甲状腺功能正常的青少年，分为两组：高正常TSH组（前25%的甲状腺功能正常TSH水平）和非高TSH组（其余75%）。我们分析了高正常TSH水平与MetS及其组成部分之间的关系。结果：TSH四分位数与MetS相关（趋势P =0.006）。高正常TSH组MetS的发生率为3.5%，非高正常TSH组为1.9% （P=0.1929）。腹部肥胖在高正常TSH组比非高TSH组更普遍（16.2%比9.6%，P=0.0153）。其他代谢产物在高正常TSH组中更为普遍，但差异不显著。高正常TSH与腹部肥胖显著相关（校正优势比1.975；95%可信区间1.104 ~ 3.531，P=0.0218）。结论：在甲状腺功能正常的青少年中，TSH四分位数与MetS之间存在显著趋势。具体来说，高正常TSH水平显示与腹部肥胖有显著关联，腹部肥胖是代谢的关键组成部分。

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来源期刊

Annals of Pediatric Endocrinology & Metabolism Multiple-

CiteScore

4.00

自引率

18.20%

发文量

审稿时长

24 weeks

期刊介绍： The Annals of Pediatric Endocrinology & Metabolism Journal is the official publication of the Korean Society of Pediatric Endocrinology. Its formal abbreviated title is “Ann Pediatr Endocrinol Metab”. It is a peer-reviewed open access journal of medicine published in English. The journal was launched in 1996 under the title of ‘Journal of Korean Society of Pediatric Endocrinology’ until 2011 (pISSN 1226-2242). Since 2012, the title is now changed to ‘Annals of Pediatric Endocrinology & Metabolism’. The Journal is published four times per year on the last day of March, June, September, and December. It is widely distributed for free to members of the Korean Society of Pediatric Endocrinology, medical schools, libraries, and academic institutions. The journal is indexed/tracked/covered by web sites of PubMed Central, PubMed, Emerging Sources Citation Index (ESCI), Scopus, EBSCO, EMBASE, KoreaMed, KoMCI, KCI, Science Central, DOI/CrossRef, Directory of Open Access Journals(DOAJ), and Google Scholar. The aims of Annals of Pediatric Endocrinology & Metabolism are to contribute to the advancements in the fields of pediatric endocrinology & metabolism through the scientific reviews and interchange of all of pediatric endocrinology and metabolism. It aims to reflect the latest clinical, translational, and basic research trends from worldwide valuable achievements. In addition, genome research, epidemiology, public education and clinical practice guidelines in each country are welcomed for publication. The Journal particularly focuses on research conducted with Asian-Pacific children whose genetic and environmental backgrounds are different from those of the Western. Area of specific interest include the following : Growth, puberty, glucose metabolism including diabetes mellitus, obesity, nutrition, disorders of sexual development, pituitary, thyroid, parathyroid, adrenal cortex, bone or other endocrine and metabolic disorders from infancy through adolescence.