Secondary metabolites with anti-inflammatory activity isolated from a marine-derived fungus Biscogniauxia sp. 8703.

IF 1.6 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2026-07-01 Epub Date: 2025-11-09 DOI:10.1080/10286020.2025.2576000

Li Zheng, Qing-Mei He, Dan He, Sen-Hua Chen, Qi-Lin Wu, Guang-Yuan Luo, Jun Chen, Heng Guo, Zhi-Bo Hu, Li-Tong Chen, Lan Liu, Jing Li

引用次数: 0

Abstract

Four new compounds (1-4), along with 22 known metabolites (5-26), were isolated from the fungus Biscogniauxia sp. 8703. The structures of the new compounds were elucidated based on NMR, MS, and ECD analysis. Compounds 1 and 2 were identified as heliannuol D analogs, which exhibited anti-inflammatory activity by inhibiting NO production in LPS-induced RAW 264.7 cell, with IC₅₀ values of 7.14 and 25.25 μM, respectively.

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海洋真菌Biscogniauxia sp. 8703中具有抗炎活性的次级代谢物。

从真菌Biscogniauxia sp. 8703中分离到4个新化合物（1 ~ 4）和22个已知代谢物（5 ~ 26）。通过核磁共振、质谱和ECD分析对新化合物的结构进行了鉴定。化合物1和2为向日葵醇D类似物，通过抑制lps诱导的RAW 264.7细胞NO生成而具有抗炎活性，IC50值分别为7.14和25.25 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.