Rana Said, Radwan Ali, Ahmed M. Amshawee, M. M. Rekha, Shaker Al-Hasnaawei, Subhashree Ray, Amrita Pal, Renu Sharma, Mosstafa Kazemi
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引用次数: 0
Abstract
Aminocarbonylation reactions represent a powerful synthetic strategy for constructing amide bonds—key structural motifs in pharmaceuticals, agrochemicals, and functional materials. In recent years, magnetic nanocatalysts have gained significant attention as efficient, sustainable, and reusable platforms for promoting these transformations. This review highlights recent developments in the design, application, and mechanistic understanding of magnetic nanocatalysts employed in aminocarbonylation reactions. Emphasis is placed on systems based on palladium, nickel, and copper nanoparticles supported on magnetically responsive materials such as Fe₃O₄, which enable facile catalyst separation and reuse via external magnetic fields. The role of surface functionalization, core–shell architectures, and ligand modification in enhancing catalytic performance is discussed in detail. In addition, we address key challenges, including metal leaching, deactivation, and scalability, and explore the growing interest in carbon monoxide surrogates for safer, greener aminocarbonylation. Outlooks on the integration of magnetic nanocatalysts with continuous-flow technologies and the potential of machine learning in catalyst design are also presented. Overall, this review underscores the significant potential of magnetic nanocatalysts in developing efficient, scalable, and environmentally responsible aminocarbonylation protocols for modern synthetic chemistry.
期刊介绍：
Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc.
Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.
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