In vivo dosimetry in head and neck cancer radiotherapy patients using an intraoral stent: prospective cohort

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2026-03-01 Epub Date: 2025-10-06 DOI:10.1016/j.oooo.2025.09.021

Lísia Daltro Borges Alves MSc , Ana Carolina dos Santos Menezes MSc , Alfredo Viamonte Marin PhD , Claudio Castelo Branco Viegas MSc , Andreia Cristina de Melo MD, PhD , Juliana Chaves Carneiro Carvalho MD , Marco Túlio Cunha Santos BSc , Bruna Lamis Alvarenga MSc , Caio Weber Mendanha Ribeiro BSc , Yara dos Santos Dabdab BSc , Thiago Bernardino da Silveira MSc , Isabele Ávila Small PhD , Daniel Cohen-Goldemberg PhD , Héliton Spíndola Antunes PhD

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引用次数: 0

Abstract

Objectives

To evaluate the radiation dose in the oral cavity structures (through in vivo dosimetry and treatment planning system) of head and neck cancer patients; and secondarily, evaluate sialometry and oral mucositis.

Study Design

This is a prospective cohort study with patients over 18 years old, diagnosed with oral cavity and major salivary glands cancer, treated with radiotherapy. Group A patients used an intraoral stent (n = 14), and those in Group B (n = 14) did not. In Group A, in vivo dosimetry was performed by positioning 2 thermoluminescent dosimeters in the intraoral stent; unstimulated and stimulated salivary flow were measured; and oral mucositis was evaluated.

Results

In vivo dosimetry demonstrated higher doses in the tumoral area in comparison with the opposite tumor area (p < .001). The planning system predicted doses in nontumor area were lower in Group A. Unstimulated sialometry was higher in Group A in the intermediate and final sessions (p < .05), and hyposalivation was more frequent in Group B (p = .015). No statistically significant differences were observed between the groups regarding the maximum grade and duration of oral mucositis (p = .499; and p = .466, respectively).

Conclusion

The intraoral stent was associated with opposite tumor area lower doses, measured using in vivo dosimetry, the first time this method was applied in studies on this device. Individuals treated with the intraoral stent presented higher salivary flows during and after radiotherapy.

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使用口内支架的头颈癌放疗患者的体内剂量测定：前瞻性队列。

目的：通过体内剂量法和治疗计划系统评价头颈癌患者口腔结构中的辐射剂量；其次，评估唾液测量和口腔黏膜炎。研究设计：这是一项前瞻性队列研究，患者年龄超过18岁，诊断为口腔和大唾液腺癌，接受放疗。A组患者使用了口内支架（n = 14）， B组患者（n = 14）未使用。A组在口腔内支架内放置2个热释光剂量仪进行体内剂量测定；测量未受刺激和受刺激的唾液流量；评估口腔黏膜炎。结果：体内剂量测定显示肿瘤区剂量高于对面肿瘤区（p < 0.001）。计划系统预测的非肿瘤区域的剂量在A组较低（p < 0.05），非刺激的唾液测量在中间和最后阶段在A组较高（p < 0.05），低渗在B组更频繁（p = 0.015）。两组口腔黏膜炎的最大程度和持续时间差异无统计学意义（p = 0.499; p = 0.466）。结论：口腔内支架与肿瘤对面区域低剂量相关，采用体内剂量法测量，该方法首次应用于该装置的研究。接受口内支架治疗的个体在放疗期间和放疗后出现较高的唾液流量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.