First documented cases of heteropaternal superfecundation in dizygotic twins from the Dominican Republic: A case report

Q3 Medicine

Forensic Science International: Reports Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI:10.1016/j.fsir.2025.100433

Thais Reyes, Rosneld Rivero, Santa Jiménez, Karla Figueroa, Eileen Riego

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Abstract

Heteropaternal superfecundation (HSF) is a rare reproductive event where two ova from the same menstrual cycle are fertilized by sperm from different men. This phenomenon challenges conventional assumptions in paternity testing, particularly for dizygotic (DZ) twins. This report describes the first two documented cases of HSF in the Dominican Republic, identified from a review of 61 DZ twin pairs undergoing kinship analysis. Genetic analysis using autosomal (aSTR) and Y-chromosome (Y-STR) markers confirmed that in both cases—one involving opposite-sex twins and the other same-sex male twins—the twins shared a mother but had different biological fathers. These findings underscore the critical importance of testing both DZ twins individually in all paternity disputes to prevent erroneous legal and social outcomes. This report serves as a guide for forensic and medical professionals facing similar complex kinship scenarios.

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多米尼加共和国异卵双胞胎异父超受精的首例记录病例：一例报告

异父超受精（HSF）是一种罕见的生殖事件，即来自同一月经周期的两个卵子与来自不同男性的精子受精。这一现象挑战了亲子鉴定的传统假设，特别是对异卵双胞胎（DZ）。本报告描述了多米尼加共和国前两例有记录的HSF病例，它们是在对61对DZ双胞胎进行亲属关系分析后发现的。利用常染色体（aSTR）和y染色体（Y-STR）标记进行的遗传分析证实，在这两种情况下——一个涉及异性双胞胎，另一个涉及同性男性双胞胎——双胞胎共享一个母亲，但有不同的生父。这些发现强调了在所有父权纠纷中对DZ双胞胎进行单独测试的重要性，以防止错误的法律和社会结果。这份报告为面临类似复杂亲属关系情况的法医和医疗专业人员提供了指南。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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