Immunoproteomics for wastewater-based health surveillance: A review

IF 14.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Science and Ecotechnology Pub Date : 2025-11-01 Epub Date: 2025-10-03 DOI:10.1016/j.ese.2025.100626

Jaxaira Maggi , Joaquin Abian , Antoni Ginebreda , Damià Barceló , Montserrat Carrascal

{"title":"Immunoproteomics for wastewater-based health surveillance: A review","authors":"Jaxaira Maggi , Joaquin Abian , Antoni Ginebreda , Damià Barceló , Montserrat Carrascal","doi":"10.1016/j.ese.2025.100626","DOIUrl":null,"url":null,"abstract":"<div><div>Wastewater-based epidemiology (WBE) offers a unique window into the health and habits of communities through the analysis of pollutants and biomarkers in sewage. Traditionally focused on small molecules, such as pharmaceuticals and illegal drugs, recent advances in environmental proteomics have expanded WBE to include large biomolecules such as proteins. Notably, novel sampling methods using polymeric probes and high-resolution mass spectrometry have facilitated the detection of human and animal proteins, both soluble and in particulate material, linking them to specific populations and industrial activities. An immunological dimension to this approach is fundamental to include the recognition of host immunoglobulins, immune-response proteins, and pathogen antigens in wastewater, potentially serving as indicators of community immune status, infection prevalence, and vaccination coverage. This review consolidates the latest advancements in environmental proteomics as applied to WBE, emphasizing an immunological perspective as a comprehensive tool for assessing population health and environmental conditions to bridge environmental monitoring, public health, and clinical diagnostics.</div></div>","PeriodicalId":34434,"journal":{"name":"Environmental Science and Ecotechnology","volume":"28 ","pages":"Article 100626"},"PeriodicalIF":14.3000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Science and Ecotechnology","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666498425001048","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/3 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Wastewater-based epidemiology (WBE) offers a unique window into the health and habits of communities through the analysis of pollutants and biomarkers in sewage. Traditionally focused on small molecules, such as pharmaceuticals and illegal drugs, recent advances in environmental proteomics have expanded WBE to include large biomolecules such as proteins. Notably, novel sampling methods using polymeric probes and high-resolution mass spectrometry have facilitated the detection of human and animal proteins, both soluble and in particulate material, linking them to specific populations and industrial activities. An immunological dimension to this approach is fundamental to include the recognition of host immunoglobulins, immune-response proteins, and pathogen antigens in wastewater, potentially serving as indicators of community immune status, infection prevalence, and vaccination coverage. This review consolidates the latest advancements in environmental proteomics as applied to WBE, emphasizing an immunological perspective as a comprehensive tool for assessing population health and environmental conditions to bridge environmental monitoring, public health, and clinical diagnostics.

Abstract Image

查看原文本刊更多论文

免疫蛋白质组学在废水健康监测中的应用综述

基于废水的流行病学（WBE）通过分析污水中的污染物和生物标志物，为了解社区的健康和习惯提供了一个独特的窗口。传统上专注于小分子，如药物和非法药物，环境蛋白质组学的最新进展已将WBE扩展到包括大型生物分子，如蛋白质。值得注意的是，使用聚合物探针和高分辨率质谱的新型采样方法促进了人类和动物蛋白质的检测，包括可溶性和颗粒物质，将它们与特定人群和工业活动联系起来。该方法的免疫学维度是基本的，包括对宿主免疫球蛋白、免疫反应蛋白和废水中的病原体抗原的识别，可能作为社区免疫状况、感染流行率和疫苗接种覆盖率的指标。本文综述了环境蛋白质组学在WBE研究中的最新进展，强调了免疫学视角作为评估人群健康和环境状况的综合工具，将环境监测、公共卫生和临床诊断联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Environmental Science and Ecotechnology Multiple-

CiteScore

20.40

自引率

6.30%

发文量

审稿时长

18 days

期刊介绍： Environmental Science & Ecotechnology (ESE) is an international, open-access journal publishing original research in environmental science, engineering, ecotechnology, and related fields. Authors publishing in ESE can immediately, permanently, and freely share their work. They have license options and retain copyright. Published by Elsevier, ESE is co-organized by the Chinese Society for Environmental Sciences, Harbin Institute of Technology, and the Chinese Research Academy of Environmental Sciences, under the supervision of the China Association for Science and Technology.