HBV antigen as a tumour antigen in adoptive TCR-T cell therapy for HBV-related HCC: rationale and clinical effectiveness

IF 11.5 2区医学 Q1 IMMUNOLOGY

Seminars in Immunology Pub Date : 2025-12-01 Epub Date: 2025-11-06 DOI:10.1016/j.smim.2025.102004

Shan He, Anthony T. Tan, Antonio Bertoletti

引用次数: 0

Abstract

Hepatocellular carcinoma developing in patients with HBV chronic infection are marked by expression of whole or partial HBV antigens through a highly tissue-specific process, determined by the hepatotropism of HBV. HBV antigens are therefore a possible target for adoptive T cell immunotherapy as their expression and, consequently, potential on-target off-tumour events, are confined to the liver compartment with no involvement of other organs. Here we summarise the research steps to develop T cell therapy that utilises viral antigen as a tumour antigen in HBV-related HCC and discuss the efficacy and the potential mechanisms of action of HBV-specific T cell receptor (TCR)-redirected T cells in phase I clinical trials.

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HBV抗原作为肿瘤抗原在HBV相关HCC过继TCR-T细胞治疗中的作用：理论基础和临床效果

HBV慢性感染患者发生肝细胞癌的标志是通过一个高度组织特异性的过程表达全部或部分HBV抗原，这是由HBV的嗜肝性决定的。因此，HBV抗原是过继性T细胞免疫治疗的可能靶标，因为它们的表达和潜在的靶外肿瘤事件局限于肝室，不涉及其他器官。在这里，我们总结了利用病毒抗原作为肿瘤抗原在hbv相关HCC中开发T细胞疗法的研究步骤，并讨论了hbv特异性T细胞受体（TCR）重定向T细胞在I期临床试验中的疗效和潜在作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Immunology 医学-免疫学

CiteScore

11.40

自引率

1.30%

发文量

审稿时长

89 days

期刊介绍： Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.