Surface analysis of sodium metamizolate as an active pharmaceutical ingredient in solid form

IF 1.8 3区化学 Q3 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

International Journal of Mass Spectrometry Pub Date : 2026-01-01 Epub Date: 2025-11-05 DOI:10.1016/j.ijms.2025.117548

Matjaž Finšgar, Katja Andrina Varda

{"title":"Surface analysis of sodium metamizolate as an active pharmaceutical ingredient in solid form","authors":"Matjaž Finšgar, Katja Andrina Varda","doi":"10.1016/j.ijms.2025.117548","DOIUrl":null,"url":null,"abstract":"<div><div>This study focuses on the surface and subsurface characterization of a pharmaceutical tablet containing sodium metamizolate (NaMET), with an emphasis on mass spectrometry using time-of-flight secondary ion mass spectrometry (ToF-SIMS). ToF-SIMS enabled the identification of NaMET-specific fragment ions, which served as signals for the determination of the spatial distribution of this active pharmaceutical ingredient (API) within the tablet matrix. A ToF-SIMS fragmentation mechanism for NaMET was proposed based on the ToF-SIMS spectra analysis measured on a NaMET reference standard. 3D ToF-SIMS imaging showed heterogeneous localization of the API across a 5 μm depth. Complementary techniques, including 3D profilometry and atomic force microscopy (AFM), provided surface roughness and morphological data, while X-ray photoelectron spectroscopy (XPS) confirmed the elemental composition and chemical states. Depth profiling by XPS further supported the non-uniform distribution of NaMET.</div></div>","PeriodicalId":338,"journal":{"name":"International Journal of Mass Spectrometry","volume":"519 ","pages":"Article 117548"},"PeriodicalIF":1.8000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Mass Spectrometry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1387380625001526","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/5 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PHYSICS, ATOMIC, MOLECULAR & CHEMICAL","Score":null,"Total":0}

引用次数: 0

Abstract

This study focuses on the surface and subsurface characterization of a pharmaceutical tablet containing sodium metamizolate (NaMET), with an emphasis on mass spectrometry using time-of-flight secondary ion mass spectrometry (ToF-SIMS). ToF-SIMS enabled the identification of NaMET-specific fragment ions, which served as signals for the determination of the spatial distribution of this active pharmaceutical ingredient (API) within the tablet matrix. A ToF-SIMS fragmentation mechanism for NaMET was proposed based on the ToF-SIMS spectra analysis measured on a NaMET reference standard. 3D ToF-SIMS imaging showed heterogeneous localization of the API across a 5 μm depth. Complementary techniques, including 3D profilometry and atomic force microscopy (AFM), provided surface roughness and morphological data, while X-ray photoelectron spectroscopy (XPS) confirmed the elemental composition and chemical states. Depth profiling by XPS further supported the non-uniform distribution of NaMET.

Abstract Image

查看原文本刊更多论文

甲基化钠作为活性药物成分在固体形态下的表面分析

本研究重点研究了一种含有甲基化钠（NaMET）的片剂的表面和亚表面表征，重点研究了使用飞行时间二次离子质谱法（ToF-SIMS）的质谱分析。ToF-SIMS能够识别namet特异性片段离子，作为确定该活性药物成分（API）在片剂基质内空间分布的信号。基于在NaMET参考标准上测量的ToF-SIMS光谱分析，提出了NaMET的ToF-SIMS碎片化机制。3D ToF-SIMS成像显示API在5 μm深度上的非均匀定位。包括3D轮廓术和原子力显微镜（AFM）在内的互补技术提供了表面粗糙度和形态数据，而x射线光电子能谱（XPS）则证实了元素组成和化学状态。XPS深度剖面进一步支持NaMET的非均匀分布。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Mass Spectrometry 物理-光谱学

CiteScore

3.60

自引率

5.60%

发文量

145

审稿时长

71 days

期刊介绍： The journal invites papers that advance the field of mass spectrometry by exploring fundamental aspects of ion processes using both the experimental and theoretical approaches, developing new instrumentation and experimental strategies for chemical analysis using mass spectrometry, developing new computational strategies for data interpretation and integration, reporting new applications of mass spectrometry and hyphenated techniques in biology, chemistry, geology, and physics. Papers, in which standard mass spectrometry techniques are used for analysis will not be considered. IJMS publishes full-length articles, short communications, reviews, and feature articles including young scientist features.