The potential of curcumin in tissue engineering and nanotechnology-based drug delivery systems: A bibliometric analysis

IF 1.3 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

European Journal of Integrative Medicine Pub Date : 2025-12-01 Epub Date: 2025-10-26 DOI:10.1016/j.eujim.2025.102575

Kaan ZIKŞAHNA , Rumeysa ADIYIL , Melisa ÖZKAN , Murat IHLAMUR

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引用次数: 0

Abstract

Introduction

Curcumin is widely investigated in tissue engineering and nanotechnology-enabled drug delivery, yet the rapidly expanding literature lacks a consolidated map to guide translation. To address this gap, we mapped global output, hotspots, and collaboration patterns on curcumin and aligned bibliometric trends with translational needs.

Methods

We conducted a Scopus-based bibliometric analysis of records published between 1997 and 2024 using a single-day snapshot (21 February 2025). A reproducible TITLE-ABS-KEY query centered on “curcumin” retrieved 12,327 documents. After retrieval, de-noising retained records that mentioned curcumin (or variants) in the title, abstract, or author keywords. We computed standard indicators (outputs, citations, subject areas, countries, institutions, authors, journals) and constructed keyword co-occurrence and collaboration networks in VOSviewer.

Results

Outputs increased sharply after 2016 and concentrated on pharmacology, biochemistry, materials science, and engineering. China (28.1 %), India (21.5 %), and the United States (12.6 %) led publication counts. Recurrent hotspots included bioavailability/controlled release, apoptosis/reactive oxygen species (ROS), hydrogels/nanofibers, and neuroprotection. Collaboration maps showed dense hubs around China, India, and the United States, while several regions were underrepresented.

Conclusion

Hotspots mirror experimental advances with nanocarriers such as PLGA, liposomes, and dendrosomes that improve curcumin stability, uptake, and therapeutic indices. Methodological transparency (single-source justification, query disclosure, de-noising) enhances reproducibility. Translational progress will benefit from harmonized in vivo models, full formulation reporting—size, polydispersity index (PDI), zeta potential, loading, and release—Good Manufacturing Practice (GMP)-compatible scale-up, and region-adapted regulatory guidance.

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姜黄素在组织工程和基于纳米技术的药物输送系统中的潜力：文献计量学分析

姜黄素在组织工程和纳米技术支持的药物传递中被广泛研究，然而迅速扩大的文献缺乏一个统一的地图来指导翻译。为了解决这一差距，我们绘制了姜黄素的全球产出、热点和合作模式，并将文献计量学趋势与翻译需求结合起来。方法采用单天快照（2025年2月21日）对1997 - 2024年间发表的文献进行了基于范围的文献计量学分析。以“curcumin”为中心的可重复TITLE-ABS-KEY查询检索了12,327个文档。检索后，去噪保留在标题、摘要或作者关键词中提到姜黄素（或变体）的记录。我们计算了标准指标（产出、引用、学科领域、国家、机构、作者、期刊），并在VOSviewer中构建了关键词共现和协作网络。结果2016年以后学术产出大幅增加，主要集中在药理学、生物化学、材料科学和工程学科。中国（28.1%）、印度（21.5%）和美国（12.6%）在发表数量上领先。反复出现的热点包括生物利用度/控释、细胞凋亡/活性氧（ROS）、水凝胶/纳米纤维和神经保护。协作地图显示，中国、印度和美国周围有密集的中心，而一些地区没有得到充分代表。结论PLGA、脂质体、树突体等纳米载体可改善姜黄素的稳定性、吸收和治疗指标。方法的透明性（单源证明、查询披露、去噪）增强了可重复性。转化进展将受益于协调一致的体内模型、完整的制剂报告大小、多分散指数（PDI）、zeta电位、装载和释放、与良好生产规范（GMP）兼容的扩大规模和适应地区的监管指导。

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来源期刊

European Journal of Integrative Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

4.70

自引率

4.00%

发文量

102

审稿时长

33 days

期刊介绍： The European Journal of Integrative Medicine (EuJIM) considers manuscripts from a wide range of complementary and integrative health care disciplines, with a particular focus on whole systems approaches, public health, self management and traditional medical systems. The journal strives to connect conventional medicine and evidence based complementary medicine. We encourage submissions reporting research with relevance for integrative clinical practice and interprofessional education. EuJIM aims to be of interest to both conventional and integrative audiences, including healthcare practitioners, researchers, health care organisations, educationalists, and all those who seek objective and critical information on integrative medicine. To achieve this aim EuJIM provides an innovative international and interdisciplinary platform linking researchers and clinicians. The journal focuses primarily on original research articles including systematic reviews, randomized controlled trials, other clinical studies, qualitative, observational and epidemiological studies. In addition we welcome short reviews, opinion articles and contributions relating to health services and policy, health economics and psychology.