Salivary oxytocin responses in mothers and full-term newborns in early skin-to-skin contact for the first 2 hours after birth: Effects of synthetic oxytocin administration and epidural analgesia in labor

IF 2.7 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuropeptides Pub Date : 2025-12-01 Epub Date: 2025-10-28 DOI:10.1016/j.npep.2025.102567

Aya Tomita, Kaori Yonezawa, Yuriko Usui, Megumi Haruna

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引用次数: 0

Abstract

Background

Epidural analgesia with synthetic oxytocin reduces maternal oxytocin levels in the early postpartum period. However, whether maternal and neonatal endogenous oxytocin levels in the first 2 h after birth are affected by drug administration during labor is unknown.

Aim

To determine the effect of drug administration during labor on maternal–newborn salivary oxytocin levels after birth.

Methods

This cohort study was conducted on 62 stable primiparous mother–newborn pairs after vaginal birth. Saliva samples were collected approximately 30 (pre-skin-to-skin contact), 60 (during skin-to-skin contact), and 120 (post-skin-to-skin contact) minutes after birth. Mother–newborn pairs were stratified by medical interventions during labor: non-drug, oxytocin-only, and epidural analgesia-with-oxytocin groups. A mixed-effects model was used to evaluate the log-transformed salivary oxytocin levels among the three groups at each repeated measure.

Results

Maternal oxytocin levels of the epidural analgesia-with-oxytocin group (β = − 0.384, standard error = 0.113) were significantly lower than those of the non-drug group at 30 min (p < 0.001). The group-time interaction analysis showed that the changes in salivary oxytocin levels in the oxytocin-only and epidural analgesia-with-oxytocin groups differed from those in the non-drug group at 60 and 120 min. Newborn oxytocin levels did not significantly differ.

Conclusions

Drug administration during labor may reduce maternal salivary oxytocin levels in the first 2 h after birth. Healthcare professionals should provide information on different approaches, such as a non-pharmacologic approach, for pain relief for primipara during labor.

查看原文本刊更多论文

母亲和足月新生儿出生后2小时皮肤接触时唾液催产素的反应：人工合成催产素和分娩时硬膜外镇痛的影响

背景：合成催产素硬膜外镇痛可降低产后早期产妇催产素水平。然而，产妇和新生儿出生后2小时内的内源性催产素水平是否受到分娩期间给药的影响尚不清楚。目的：探讨产程给药对分娩后母婴唾液催产素水平的影响。方法：对62对阴道分娩后稳定的初产妇进行队列研究。唾液样本在出生后大约30分钟（皮肤接触前）、60分钟（皮肤接触期间）和120分钟（皮肤接触后）采集。在分娩过程中，根据医疗干预对母婴进行分层：非药物组、仅使用催产素组和硬膜外使用催产素组。采用混合效应模型评估三组在每次重复测量时的对数转化唾液催产素水平。结果：催产素硬膜外镇痛组30 min时产妇催产素水平（β = - 0.384，标准误差= 0.113）显著低于非药物组(p)。结论：分娩时给药可降低产妇产后前2 h唾液催产素水平。医疗保健专业人员应提供不同方法的信息，如非药物方法，缓解分娩期间初产妇的疼痛。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.