{"title":"Probiotic-intestinal epithelium crosstalk: mechanisms of adhesion, signalling, and immunomodulation.","authors":"Carolina Maldonado-Galdeano, Silvia Inés Cazorla, Roy Fuller, Ricardo Weill, Gabriela Perdigón","doi":"10.1080/09637486.2025.2582569","DOIUrl":null,"url":null,"abstract":"<p><p>A large number of studies have highlighted the important role of probiotics in maintaining intestinal homeostasis and promoting host health. Although, several mechanisms have been proposed in recent years the exact mechanisms by which probiotic exert their effect on the immune system are not completely understood. However, intestinal epithelial cells (IEC) have an undisputed participation in the initial stages of communication between probiotics and host cells. This review summarises the current knowledge on the interaction of probiotics with IEC and the consequent stimulation of gut immune cells. In addition, it emphasises the importance of probiotics adhesion to the intestinal mucus or to the IEC as a crucial step to sustain the gut immune surveillance, ensure the probiotic efficacy and promote the activation of immune cells in organs beyond the gut.</p>","PeriodicalId":14087,"journal":{"name":"International Journal of Food Sciences and Nutrition","volume":" ","pages":"784-797"},"PeriodicalIF":3.7000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Food Sciences and Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1080/09637486.2025.2582569","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A large number of studies have highlighted the important role of probiotics in maintaining intestinal homeostasis and promoting host health. Although, several mechanisms have been proposed in recent years the exact mechanisms by which probiotic exert their effect on the immune system are not completely understood. However, intestinal epithelial cells (IEC) have an undisputed participation in the initial stages of communication between probiotics and host cells. This review summarises the current knowledge on the interaction of probiotics with IEC and the consequent stimulation of gut immune cells. In addition, it emphasises the importance of probiotics adhesion to the intestinal mucus or to the IEC as a crucial step to sustain the gut immune surveillance, ensure the probiotic efficacy and promote the activation of immune cells in organs beyond the gut.
期刊介绍：
The primary aim of International Journal of Food Sciences and Nutrition is to integrate food science with nutrition. Improvement of knowledge in human nutrition should always be the final objective of submitted research. It''s an international, peer-reviewed journal which publishes high quality, original research contributions to scientific knowledge. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
