Biology of hepatitis B virus DNA integration and its impact on antiviral R&D

IF 4.3 2区医学 Q1 PHARMACOLOGY & PHARMACY

Antiviral research Pub Date : 2025-12-01 Epub Date: 2025-11-04 DOI:10.1016/j.antiviral.2025.106305

Lottida Phondeth , Thomas Tu

引用次数: 0

Abstract

Hepatitis B virus (HBV) drastically increases the risk of developing liver cirrhosis and hepatocellular carcinoma (HCC) in the ∼300 million people with chronic hepatitis B infections. HBV reproduces through an epigenetic circular genome, but can occasionally integrate into the host genome as a replication-defective form. These integrated forms have been reported to contribute to virus persistence and hepatocarcinogenesis. In this review, we highlight the effects of current and novel treatment under development on HBV DNA integrations and provide areas of potential research to develop more effective therapies that target the underlying drivers of persistence and pathogenesis.

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乙型肝炎病毒DNA整合生物学及其对抗病毒药物研发的影响

乙型肝炎病毒（HBV）大大增加了约3亿慢性乙型肝炎感染者发生肝硬化和肝细胞癌（HCC）的风险。HBV通过表观遗传环状基因组繁殖，但偶尔也会以复制缺陷形式整合到宿主基因组中。据报道，这些整合形式有助于病毒的持久性和肝癌的发生。在这篇综述中，我们强调了当前和正在开发的新型治疗方法对HBV DNA整合的影响，并提供了潜在的研究领域，以开发针对持久性和发病机制的潜在驱动因素的更有效的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antiviral research 医学-病毒学

CiteScore

17.10

自引率

3.90%

发文量

157

审稿时长

34 days

期刊介绍： Antiviral Research is a journal that focuses on various aspects of controlling viral infections in both humans and animals. It is a platform for publishing research reports, short communications, review articles, and commentaries. The journal covers a wide range of topics including antiviral drugs, antibodies, and host-response modifiers. These topics encompass their synthesis, in vitro and in vivo testing, as well as mechanisms of action. Additionally, the journal also publishes studies on the development of new or improved vaccines against viral infections in humans. It delves into assessing the safety of drugs and vaccines, tracking the evolution of drug or vaccine-resistant viruses, and developing effective countermeasures. Another area of interest includes the identification and validation of new drug targets. The journal further explores laboratory animal models of viral diseases, investigates the pathogenesis of viral diseases, and examines the mechanisms by which viruses avoid host immune responses.