Sensory afferents in the mammary papilla are eliminated during the lactation

IF 2.2 4区医学 Q3 NEUROSCIENCES

Neuroscience Letters Pub Date : 2026-01-01 Epub Date: 2025-11-04 DOI:10.1016/j.neulet.2025.138441

Kei Nakayama , Kotoko Suzuki , Yukiko Marunaka , Mari Kondo , Yuji Yokouchi , Naoki Takeda , Kenichi Yamamura , Hiroshi Hasegawa

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引用次数: 0

Abstract

Importance of breastfeeding is well recognized, since it supports the survival of mammalian infants. The mammary papilla, a specialized skin region for breastfeeding, acts as a vital interface between mother and infant: perceiving the suckling to trigger the milk ejection reflex in mother and transporting milk from mother to infants. Despite its crucial roles in breastfeeding, the histological and cellular changes in the mammary papilla during lactation remain poorly understood. In this study, we focused on the sensory afferent projection mediating somatosensory perception. Our observation revealed that the mammary papilla is innervated by non-peptidergic C-fibers, which engage in the mechanical nociception. Moreover, we found that these sensory afferents are eliminated in the mammary papilla of lactating females. These results propose the lactation-associated elimination of sensory afferents in the mammary papilla as a novel mechanism adaptive for the breastfeeding.

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乳突中的感觉传入在哺乳期被消除。

母乳喂养的重要性是公认的，因为它支持哺乳动物婴儿的生存。乳突是母乳喂养的一个特殊皮肤区域，它是母亲和婴儿之间的重要接口：感知哺乳，触发母亲的乳汁反射，并将乳汁从母亲输送给婴儿。尽管它在母乳喂养中起着至关重要的作用，但哺乳期间乳腺乳头的组织学和细胞变化仍然知之甚少。在本研究中，我们重点研究了感觉传入投射介导的体感觉知觉。我们的观察表明，乳腺乳头受非肽能性c -纤维支配，参与机械性伤害感觉。此外，我们发现这些感觉传入在哺乳期雌性的乳腺乳头中被消除。这些结果表明，哺乳相关的乳腺乳头感觉传入的消除是一种适应母乳喂养的新机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

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