Artificial intelligence–powered biofoundries for protein engineering and metabolic engineering

IF 7.8 2区工程技术 Q1 BIOCHEMICAL RESEARCH METHODS

Current opinion in biotechnology Pub Date : 2025-12-01 Epub Date: 2025-11-04 DOI:10.1016/j.copbio.2025.103380

Junyu Chen , Nilmani Singh , Jingxia Lu , Stephan T. Lane , Huimin Zhao

引用次数: 0

Abstract

Synthetic biology is rapidly evolving through the integration of artificial intelligence (AI) and automated biofoundries. This convergence accelerates the design–build–test–learn cycle, shifting protein engineering and metabolic engineering from labor-intensive manual experimentation to autonomous experimentation. This review summarizes recent advances in workflow development, AI models, and their integration with biofoundries for automated or autonomous protein engineering and metabolic engineering. Particularly, we highlight the potential of AI-powered biofoundries for accelerated scientific discovery and innovation in synthetic biology.

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用于蛋白质工程和代谢工程的人工智能驱动生物铸造厂。

通过人工智能（AI）和自动化生物铸造厂的融合，合成生物学正在迅速发展。这种融合加速了设计-构建-测试-学习的周期，将蛋白质工程和代谢工程从劳动密集型的人工实验转变为自主实验。本文综述了工作流开发、人工智能模型及其与生物铸造厂在自动化或自主蛋白质工程和代谢工程中的集成方面的最新进展。我们特别强调了人工智能驱动的生物铸造厂在加速合成生物学科学发现和创新方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in biotechnology 工程技术-生化研究方法

CiteScore

16.20

自引率

2.60%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time. As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows. COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.