Association of Liver Fat Content With Carotid Endothelial Function in Patients With Newly Diagnosed Type 2 Diabetes Mellitus and Pre-Diabetes Mellitus.

IF 2.7 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Angiology Pub Date : 2026-09-01 Epub Date: 2025-11-06 DOI:10.1177/00033197251384344

Yan Zhu, Yun-Sheng Wang, Gui-Ping Zhang, Fang Ma, Jin-Xiang Xia, Hu Lian, Yong-Hong Cao, Rong Zhang, Jun Ye, Wu Dai

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引用次数: 0

Abstract

This study aimed to compare carotid atherosclerotic indicators among patients with newly diagnosed type 2 diabetes mellitus (NT2DM), pre-diabetes mellitus (PDM), and healthy controls (HCs), and to investigate associations between nonalcoholic fatty liver disease (NAFLD) and carotid atherosclerosis. A total of 240 participants were enrolled (120 NT2DM, 60 PDM, and 60 HCs). Liver fat content (LFC) was assessed using proton magnetic resonance spectroscopy ([¹H]-MRS). Carotid intima-media thickness (CIMT) and carotid pulse wave velocity (PWV) at the beginning (BS-PWV) and end of systole (ES-PWV) were measured by ultrasonography. The levels of LFC were significantly higher in NT2DM (14.57% ± 6.49%) and PDM (11.44% ± 5.62%) than in HCs (5.73% ± 4.08%; P=.000). The prevalence of NAFLD was 66.7% in NT2DM, 38.3% in PDM, and 25.0% in HCs. CIMT, BS-PWV, and ES-PWV were significantly elevated in NT2DM compared with PDM and HCs (all P < .05). Multiple linear regression (MLR) analyses showed LFC and triglycerides were strong contributors to both BS-PWV and ES-PWV. Elevated LFC and NAFLD prevalence in NT2DM, together with their associations with carotid atherosclerosis, suggest a potential link between NAFLD and cardiovascular disease in T2DM.

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新诊断2型糖尿病及糖尿病前期患者肝脂肪含量与颈动脉内皮功能的关系

本研究旨在比较新诊断的2型糖尿病（NT2DM）、糖尿病前期（PDM）和健康对照（hc）患者的颈动脉粥样硬化指标，并探讨非酒精性脂肪性肝病（NAFLD）与颈动脉粥样硬化之间的关系。共纳入240名参与者（120名NT2DM， 60名PDM和60名hc）。采用质子磁共振波谱法（[1H]-MRS）测定肝脏脂肪含量（LFC）。超声测量颈动脉内膜-中膜厚度（CIMT）、收缩期初（BS-PWV）和收缩期末（ES-PWV）颈动脉脉波速度（PWV）。NT2DM组LFC水平（14.57%±6.49%）和PDM组（11.44%±5.62%）明显高于hc组（5.73%±4.08%，P= 0.000）。NT2DM组NAFLD患病率为66.7%，PDM组为38.3%，hc组为25.0%。与PDM和hc相比，NT2DM患者的CIMT、BS-PWV和ES-PWV均显著升高

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来源期刊

Angiology 医学-外周血管病

CiteScore

5.50

自引率

14.30%

发文量

180

审稿时长

6-12 weeks

期刊介绍： A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days