Sirtuin modulators: a review of patents from 2020 to 2024.

IF 4.7 2区医学 Q1 CHEMISTRY, MEDICINAL

Expert Opinion on Therapeutic Patents Pub Date : 2026-01-01 Epub Date: 2025-11-06 DOI:10.1080/13543776.2025.2585821

Emanuele Fabbrizi, Francesco Fiorentino, Antonello Mai, Dante Rotili

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引用次数: 0

Abstract

Introduction: Sirtuins have gained significant prominence in scientific research due to their involvement in a wide array of biological processes, including DNA repair, genome stability, transcription modulation, and signal transduction. Dysregulation of their function has been implicated in various pathologies, including cancer, where sirtuins exhibit context-dependent effects. Consequently, the development of sirtuin inhibitors and activators remains an exceptionally important field of research, focusing on the design of selective modulators targeting individual sirtuin isoforms.

Areas covered: This review includes the patents regarding sirtuin modulators released from 2020 to 2024 and provides a concise overview of the most relevant modulators developed so far. Relevant patents were systematically identified through comprehensive searches in PubMed (https://pubmed.ncbi.nlm.nih.gov), Google Patents (https://patents.google.com), and Espacenet (https://worldwide.espacenet.com).

Expert opinion: Sirtuin modulators are pivotal in addressing aging, metabolism, cancer, and neurodegeneration. Sirtuins regulate key cellular processes like DNA repair, genome stability, and mitochondrial function. Activators show promise in mitigating many age-related diseases such as type 2 diabetes and neurodegeneration. Inhibitors demonstrate efficacy in oncology and neurodegenerative conditions. Advances in PROTAC technology enable selective degradation of specific isoforms, enhancing therapeutic precision. With progress in drug design and high-throughput screening, sirtuin modulators hold immense potential to revolutionize treatments for complex medical challenges.

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Sirtuin调节剂：2020年至2024年专利回顾。

导读：Sirtuins在科学研究中获得了显著的突出地位，因为它们参与了广泛的生物过程，包括DNA修复、基因组稳定性、转录调节和信号转导。sirtuins的功能失调与多种病理有关，包括癌症，其中sirtuins表现出上下文依赖的作用。因此，sirtuin抑制剂和激活剂的开发仍然是一个非常重要的研究领域，重点是针对单个sirtuin同种异构体设计选择性调节剂。涵盖领域：本综述包括2020年至2024年发布的有关sirtuin调制剂的专利，并提供了迄今为止开发的最相关调制剂的简要概述。通过PubMed （https://pubmed.ncbi.nlm.nih.gov）、谷歌patents （https://patents.google.com）和Espacenet (https://worldwide.espacenet.com).Expert)的综合检索系统地确定了相关专利。观点：Sirtuin调节剂在解决衰老、代谢、癌症和神经变性方面至关重要。Sirtuins调节关键的细胞过程，如DNA修复、基因组稳定性和线粒体功能。激活剂有望缓解许多与年龄有关的疾病，如2型糖尿病和神经变性。抑制剂在肿瘤和神经退行性疾病中表现出疗效。PROTAC技术的进步使特定同种异构体的选择性降解成为可能，提高了治疗精度。随着药物设计和高通量筛选的进步，sirtuin调节剂具有巨大的潜力，可以彻底改变复杂医疗挑战的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Opinion on Therapeutic Patents 医学-药学

CiteScore

12.10

自引率

1.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Opinion on Therapeutic Patents (ISSN 1354-3776 [print], 1744-7674 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on recent pharmaceutical patent claims, providing expert opinion the scope for future development, in the context of the scientific literature. The Editors welcome: Reviews covering recent patent claims on compounds or applications with therapeutic potential, including biotherapeutics and small-molecule agents with specific molecular targets; and patenting trends in a particular therapeutic area Patent Evaluations examining the aims and chemical and biological claims of individual patents Perspectives on issues relating to intellectual property The audience consists of scientists, managers and decision-makers in the pharmaceutical industry and others closely involved in R&D Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days.