A demethylation chloroisosulochrin and a chromone metabolite from the endophytic fungus Penicilium sp.

IF 1.6 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2026-08-01 Epub Date: 2025-11-03 DOI:10.1080/10286020.2025.2579152

Ke-Liang Chen, Xue Wang, Yang Liu, Yun-Bao Liu

引用次数: 0

Abstract

A newly discovered chloroisosulochrin derivative, involving demethychloroisosul (1), and a novel chromone metabolite, reduchromone (2), were extracted from Penicilium sp., an endophytic fungus residing in Rhododendron molle. The structures of these compounds were elucidated through a comprehensive analysis of their 1D and 2D NMR and HRESIMS data. In addition, the X-ray diffraction analysis of demethychloroisosul (1) is the first example to confirm the structure of chloroisosulochrin by single-crystal data. Notably, demethychloroisosul (1) exhibited moderate cytotoxic efficacy against HepG2 liver cancer cells, with a half-maximal inhibitory concentration value of 30.18 μM.

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内生真菌青霉菌的一种去甲基氯异氯氯啉和一种色素代谢物。

从杜鹃花内生真菌青霉（Penicilium sp.）中提取了一种新发现的氯异氯酚衍生物，包括去甲基氯异氯酚(1)和一种新的色素代谢物还原色素(2)。这些化合物的结构通过对它们的一维和二维NMR和HRESIMS数据的综合分析得到了阐明。此外，对二甲基氯异氯酚(1)的x射线衍射分析是第一个用单晶数据证实氯异氯酚结构的例子。值得注意的是，去甲基氯异硫醚(1)对HepG2肝癌细胞具有中等的细胞毒作用，半最大抑制浓度值为30.18 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.