Mediating Role of Insulin Resistance in the Association Between Body Composition and Hypertension.

IF 2.9 Q2 PERIPHERAL VASCULAR DISEASE

High Blood Pressure & Cardiovascular Prevention Pub Date : 2026-01-01 Epub Date: 2025-11-04 DOI:10.1007/s40292-025-00754-5

Qingfang Deng, Hao Kang, Yu Cao, Rui Tian, Dengke Chen, Hui Yu, Jioajiao Zhu, Yanling He, Jie Zhang, Xing Liu, Jie Sheng, Sufang Wang

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引用次数: 0

Abstract

Introduction: Hypertension, a major cardiovascular risk, is affected by body composition and metabolism.

Aim: We assessed the associations of body composition with hypertension and the mediating role of insulin resistance (IR).

Methods: In Hefei Hongsifang Company, 743 employees aged 40-60 were recruited consecutively. Logistic regression was used to assess the association between body composition and hypertension risk. Mediation analysis was conducted to explore the mediating role of IR between body composition and hypertension risk.

Results: Individuals with higher body fat percentage (BF%) (OR = 2.44, 95% CI 1.64-3.65, P < 0.001) and Visceral adiposity index (VAI) (OR = 2.22, 95% CI 1.39-3.55, P < 0.001) had significantly higher odds of hypertension. Conversely, higher levels of skeletal muscle mass percentage (SMM%) (OR = 0.35, 95% CI 0.21-0.56, P < 0.001), total body water percentage (TBW%) (OR = 0.36, 95% CI 0.23-0.59, P < 0.001), and bone mineral content percentage (BMC%) (OR = 0.34, 95% CI 0.21-0.54, P < 0.001) were all linked to lower odds of hypertension. IR significantly mediated the associations between body composition and hypertension risk. The mediation proportions were as follows: 29.4% for BF%, 61.5% for VAI, 33.7% for SMM%, 34.9% for TBW%, and 31.4% for BMC%.

Conclusion: Our study demonstrated that, in middle-aged individuals, lower BF% and VAI, as well as higher SMM%, TBW%, and BMC%, were independently associated with a reduced risk of hypertension. IR partially mediated the associations between body composition and hypertension.

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胰岛素抵抗在身体成分与高血压关系中的中介作用。

高血压是一种主要的心血管疾病，它受身体成分和新陈代谢的影响。目的：我们评估身体成分与高血压的关系以及胰岛素抵抗（IR）的中介作用。方法：对合肥宏四方公司743名40 ~ 60岁员工进行连续招募。采用Logistic回归评估身体成分与高血压风险之间的关系。通过中介分析，探讨IR在身体成分与高血压风险之间的中介作用。结果：体脂率（BF%）较高的个体（OR = 2.44, 95% CI 1.64-3.65， P）结论：我们的研究表明，在中年个体中，较低的BF%和VAI，以及较高的SMM%、TBW%和BMC%与高血压风险降低独立相关。IR部分介导了身体成分与高血压之间的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

High Blood Pressure & Cardiovascular Prevention PERIPHERAL VASCULAR DISEASE-

CiteScore

5.70

自引率

3.30%

发文量

期刊介绍： High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes: Invited ''State of the Art'' reviews. Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.