Expansion strategies for Vδ2 γδT cells in cancer immunotherapy: Activation, cytokines, and culture conditions.

IF 3.6 Q3 ONCOLOGY

World journal of clinical oncology Pub Date : 2025-10-24 DOI:10.5306/wjco.v16.i10.110466

Natalia Lehman, Michal Zarobkiewicz

引用次数: 0

Abstract

The γδT cells are an emerging class of immune effectors with potent antitumor activity, bridging innate and adaptive immunity. Their unique ability to recognise stress-induced ligands independently of major histocompatibility complex restriction makes them attractive candidates for cancer immunotherapy. However, the clinical application of γδT cells requires efficient in vitro expansion strategies to generate large numbers of functional cells. This mini-review explores the latest advancements in γδT cell expansion protocols, focusing on key activation stimuli, cytokine support, and culture conditions that optimise proliferation and cytotoxicity.

Abstract Image

查看原文本刊更多论文

肿瘤免疫治疗中Vδ2 γδT细胞的扩增策略：激活、细胞因子和培养条件。

γδT细胞是一类新兴的免疫效应器，具有很强的抗肿瘤活性，是先天免疫和适应性免疫的桥梁。它们独立于主要组织相容性复合体的限制识别应激诱导配体的独特能力使它们成为癌症免疫治疗的有吸引力的候选者。然而，γδT细胞的临床应用需要高效的体外扩增策略来产生大量的功能细胞。这篇迷你综述探讨了γδT细胞扩增方案的最新进展，重点关注关键的激活刺激、细胞因子支持和优化增殖和细胞毒性的培养条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

World journal of clinical oncology ONCOLOGY-

自引率

0.00%

发文量

585

期刊介绍： The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.