The incidence of depression and its associated risk factors among diabetic foot ulcers patients: A meta-analysis and systematic review

IF 2.5 3区医学 Q2 DERMATOLOGY

Journal of tissue viability Pub Date : 2025-11-01 Epub Date: 2025-10-25 DOI:10.1016/j.jtv.2025.100964

Yuai Ying, Ying Lv, Hongfang Zhu, Yini Zhang, Xiaowen Fang

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引用次数: 0

Abstract

Objective

This study aims to investigate the incidence of depression and its associated risk factors among patients with diabetic foot ulcers (DFU), thereby providing an evidence-based foundation to facilitate early clinical intervention strategies.

Method

A comprehensive computerized literature search was conducted to identify studies examining the incidence and/or risk factors of depression among patients with DFU. The retrieved literature was selected according to predefined inclusion and exclusion criteria. Meta-analysis was performed using Stata 18.0 software to assess the incidence of depression among DFU patients.

Results

A systematic review of the literature identified 19 eligible studies encompassing a total of 1369 patients. The incidence of depression among patients with DFU was 45 %. The subgroup analysis identified that age, the ulcer duration and Wagner ulcer classification were significant risk factors associated with depressive symptoms among DFU patients (P < 0.05).

Conclusion

Depression has a high incidence among DFU patients. Clinical healthcare professionals should implement early, targeted interventions addressing relevant risk factors to mitigate its occurrence.

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糖尿病足溃疡患者抑郁发生率及其相关危险因素：荟萃分析和系统回顾

目的：探讨糖尿病足溃疡（DFU）患者抑郁发生率及其相关危险因素，为临床早期干预策略提供循证依据。方法：进行全面的计算机文献检索，以确定检查DFU患者抑郁发生率和/或危险因素的研究。根据预定义的纳入和排除标准选择检索到的文献。采用Stata 18.0软件进行meta分析，评估DFU患者抑郁发生率。结果：系统回顾了19项符合条件的研究，共纳入1369例患者。DFU患者抑郁发生率为45%。亚组分析发现，年龄、溃疡病程、Wagner溃疡分型是影响DFU患者抑郁症状的重要危险因素(P)。临床卫生保健专业人员应尽早实施针对相关风险因素的有针对性的干预措施，以减轻其发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of tissue viability DERMATOLOGY-NURSING

CiteScore

3.80

自引率

16.00%

发文量

110

审稿时长

>12 weeks

期刊介绍： The Journal of Tissue Viability is the official publication of the Tissue Viability Society and is a quarterly journal concerned with all aspects of the occurrence and treatment of wounds, ulcers and pressure sores including patient care, pain, nutrition, wound healing, research, prevention, mobility, social problems and management. The Journal particularly encourages papers covering skin and skin wounds but will consider articles that discuss injury in any tissue. Articles that stress the multi-professional nature of tissue viability are especially welcome. We seek to encourage new authors as well as well-established contributors to the field - one aim of the journal is to enable all participants in tissue viability to share information with colleagues.