Lower Urinary Tract Symptoms in Patients with Congenital Genitourinary Anomalies.

IF 3.2 2区医学 Q2 UROLOGY & NEPHROLOGY

Current Urology Reports Pub Date : 2025-10-30 DOI:10.1007/s11934-025-01298-w

Tijesunimi Oni, Alex Simpkins, Nischal Ada, Catherine Robey, Heather Di Carlo

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Abstract

Purpose of review: This review synthesizes the recent literature on lower urinary tract symptoms in pediatric patients with congenital conditions. We will discuss emerging insights from multiple studies on pathophysiology, prevalence, clinical impact, management strategies, and long-term outcomes.

Recent findings: Surgical advancements have increased early continence rates to 80% in exstrophy-epispadias complex (EEC), but attrition of continence remains a challenge. Studies have shown 40% of males with PUV and 80% of patients with EEC report moderate or severe LUTS which significantly impact quality of life. LUTS in patients with congenital anomalies remains a challenge in pediatric urology. Patients require individualized, lifelong management strategies. Future research should include standardizing continence definitions and assessing comparative effectiveness of treatments to enhance patient-centered outcome metrics. A multidisciplinary approach is critical to promoting sustained improvements in quality of life for individuals living with congenital genitourinary anomalies.

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先天性泌尿生殖系统异常患者的下尿路症状

综述目的：本综述综合了最近关于先天性儿童下尿路症状的文献。我们将讨论来自病理生理学、患病率、临床影响、管理策略和长期结果等多项研究的新见解。最近的研究发现：外科手术的进步使腹膜外裂-上膈复合（EEC）的早期失禁率提高到80%，但失禁的消除仍然是一个挑战。研究表明，40%的男性PUV患者和80%的EEC患者报告中度或重度LUTS，这显著影响生活质量。先天性畸形患者的LUTS仍然是儿科泌尿外科的一个挑战。患者需要个性化的终身管理策略。未来的研究应包括标准化失禁定义和评估治疗的比较有效性，以提高以患者为中心的结果指标。多学科的方法是至关重要的，以促进持续改善生活质量的个人生活与先天性泌尿生殖系统异常。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Urology Reports UROLOGY & NEPHROLOGY-

CiteScore

4.60

自引率

3.80%

发文量

期刊介绍： This journal intends to review the most important, recently published findings in the field of urology. By providing clear, insightful, balanced contributions by international experts, the journal elucidates current and emerging approaches to the care and prevention of urologic diseases and conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as benign prostatic hyperplasia, erectile dysfunction, female urology, and kidney disease. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.