Evolving Neoadjuvant, Adjuvant, and Concurrent Systemic Therapy Strategies in Head and Neck Squamous Carcinoma

IF 1.9 4区 医学 Q3 OTORHINOLARYNGOLOGY
Otolaryngologic Clinics of North America Pub Date : 2026-02-01 Epub Date: 2025-10-27 DOI:10.1016/j.otc.2025.08.022
Nandini Menon MBBS, MD, DrNB
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引用次数: 0
头颈部鳞状癌的新辅助、辅助和同步全身治疗策略的发展。
细胞毒性化疗在新辅助治疗中的作用,除了在喉保存的情况下,还没有被较早的研究很好地确立。人们正在探索新的新辅助策略,例如将免疫检查点抑制剂纳入新辅助/围手术期,将化疗与ICI和/或节律疗法结合使用,以及使用新辅助化疗-免疫疗法来适应放射治疗的反应降级。IAP(细胞凋亡蛋白抑制剂)拮抗剂是一种正在研究的用于HNSCC的新型药物,但在III期环境中尚未显示出益处。
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来源期刊
CiteScore
3.00
自引率
0.00%
发文量
152
审稿时长
6-12 weeks
期刊介绍: Otolaryngologic Clinics of North America updates you on the latest trends in patient management; keeps you up to date on the newest advances; and provides a sound basis for choosing treatment options. Each issue focuses on a single topic in otolaryngology and is presented under the direction of an experienced guest editor.
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