Impact of morphologically tuned silica nanoparticles on the invasive freshwater bivalve Limnoperna fortunei

IF 4.6 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-12-01 Epub Date: 2025-10-30 DOI:10.1016/j.etap.2025.104857

Gabriel O. Ostapchuk , Analía Ale , Victoria S. Andrade , Gisela L. Poletta , Luciana Montalto , Florencia M. Rojas Molina , Martín F. Desimone , Paolo N. Catalano

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引用次数: 0

Abstract

Silica nanoparticles (SiNP) have a high global production volume, but their toxicity is far from being completely understood. In this study, we synthesized SiNP with distinct morphological features: dense SiNP (dSiNP), conventional mesoporous SiNP (MSN), and two types of flower-like dendritic mesoporous SiNP with a stellate lamellar structure: one using ibuprofen (FLW-IBU) and one using sodium salicylate (FLW-NaSal) as auxiliary templates. To assess their toxicological impact, we conducted a 96-hour bioassay exposing the freshwater bivalve Limnoperna fortunei to 10 µg/mL of these varied SiNP. Exposure to dSiNP increased superoxide dismutase and glutathione S-transferase enzyme activities in the soft tissue of bivalves. Lipid peroxidation levels also augmented following exposure to both dSiNP and MSN. We observed no significant alterations in tissular damage markers across treatments. Neither FLW-IBU nor FLW-NaSal induced any deleterious effect, indicating they are less detrimental to L. fortunei. These findings contribute to the safe-by-design development of nanomaterials.

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形态调谐二氧化硅纳米颗粒对入侵淡水双壳动物的影响

二氧化硅纳米颗粒（SiNP）的全球产量很高，但其毒性还远未完全了解。在本研究中，我们合成了具有不同形态特征的SiNP：致密SiNP (dSiNP)，常规介孔SiNP (MSN)，以及两种具有星状片层结构的花状树突状SiNP：一种是用布洛芬（FLW-IBU）作为辅助模板，一种是用水杨酸钠（FLW-NaSal）作为辅助模板。为了评估它们的毒理学影响，我们对淡水双壳动物fortunei Limnoperna进行了96小时的生物测定，将这些不同的SiNP暴露在10 µg/mL中。暴露于dSiNP增加了双壳类软体中超氧化物歧化酶和谷胱甘肽s -转移酶的活性。脂质过氧化水平在暴露于dSiNP和MSN后也增加。我们观察到组织损伤标志物在治疗过程中没有显著变化。FLW-IBU和flw -鼻腔均未引起任何有害作用，表明它们对L. fortunei的危害较小。这些发现有助于纳米材料设计安全的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.