{"title":"Modified Cued Recall Test for the Diagnosis of Alzheimer's Disease in a Greek Sample of Adults With Down Syndrome: A Preliminary Study.","authors":"Raphaella Paradisi, Eleni Baldimtsi, Panagiotis Ntailakis, Georgios Ntritsos, Georgia Papantoniou, Anastasia Konsta, Magdalini Tsolaki","doi":"10.1352/1944-7558-130.6.503","DOIUrl":null,"url":null,"abstract":"<p><p>Diagnosing Alzheimer's disease (AD) in adults with Down syndrome remains challenging due to preexisting intellectual disability (ID) and lack of specialized assessments. This was a cross-sectional multicenter study examining the capability of the Greek version of the modified Cued Recall Test (mCRT) to identify AD in DS adults. Analysis showed statistically significant negative correlations between age and scores on all mCRT measures. Statistically significant differences were detected between ID levels and all mCRT main scores and between the two diagnostic groups and performance at immediate and delayed recall. ROC analysis revealed an optimal cut-off score of 26.5 (0-36). In conclusion, mCRT is a highly sensitive tool for detecting AD in adults with DS.</p>","PeriodicalId":51508,"journal":{"name":"Ajidd-American Journal on Intellectual and Developmental Disabilities","volume":"130 6","pages":"503-511"},"PeriodicalIF":2.3000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ajidd-American Journal on Intellectual and Developmental Disabilities","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1352/1944-7558-130.6.503","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"EDUCATION, SPECIAL","Score":null,"Total":0}
引用次数: 0
Abstract
Diagnosing Alzheimer's disease (AD) in adults with Down syndrome remains challenging due to preexisting intellectual disability (ID) and lack of specialized assessments. This was a cross-sectional multicenter study examining the capability of the Greek version of the modified Cued Recall Test (mCRT) to identify AD in DS adults. Analysis showed statistically significant negative correlations between age and scores on all mCRT measures. Statistically significant differences were detected between ID levels and all mCRT main scores and between the two diagnostic groups and performance at immediate and delayed recall. ROC analysis revealed an optimal cut-off score of 26.5 (0-36). In conclusion, mCRT is a highly sensitive tool for detecting AD in adults with DS.
期刊介绍：
The American Journal on Intellectual and Developmental Disabilities (Print ISSN: 1944–7515; Online ISSN: 1944–7558) is published by the American Association on Intellectual and Developmental Disabilities. It is a scientifi c, scholarly, and archival multidisciplinary journal for reporting original contributions of the highest quality to knowledge of intellectual disabilities, its causes, treatment, and prevention.
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