[The results of the detection of specific IgG antibodies to Ebola virus (Filoviridae: Orthoebolavirus) in residents of the Republic of Guinea after the end of the epidemic].
E V Naidenova, M Y Kartashov, I S Shulgina, S A Pyankov, M A Kulagin, M B Bah, I Nourdine, M N'Fally, V Konomou, M S Traore, S Boumbaly, V V Kutyrev
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引用次数: 0
Abstract
Introduction: In 2014-2016, an epidemic of Ebola virus disease (EVD) was registered in Guinea. In 2021, EVD cases were repeated in the region. The importance of studying the duration of post-infection immunity to the Ebola virus in the body of convalescents is due to the fact that after the end of the epidemic they can be the main sources of infection. One of the indicators of the pathogen circulation in a certain area is the detection of specific IgG antibodies in the blood sera of the inhabitants. The aim of the study is to identify IgG immunoglobulins to Ebola virus in the blood sera of reconvalescents and practically healthy residents of the Republic of Guinea after the end of the epidemic.
Materials and methods: The ELISA method was used to test the blood sera of 9 patients treated at the NKDCEM hospital (Kindia), collected after the end of the disease and up to 72 months after recovery, and 3939 blood serum samples from practically healthy residents of Guinea.
Results: IgG antibodies in the blood sera of reconvalescents a month after recovery were detected in a titer of up to 1 : 800. By 12 months, the antibody level decreased to 1 : 100 and remained at this level for up to 48 months. After 6 years of observation, no antibodies were registered. Among the 3939 blood samples from healthy residents, IgG immunoglobulins to the Ebola virus were detected in 5.6%. Most of the positive samples were collected in Forest Guinea (7.7%), and a smaller part in Upper Guinea (4.5%). The maximum percentage of positive samples was detected in people over 70 years of age (12.3%).
Conclusion: In our case, it was shown that a high level of post-infection immunity in the blood sera of patients with EVD persists for the first 6 months, this corresponds to the data obtained by other authors, and does not exclude the possibility of re-infection. The highest level of the seroprevalence is registered in Forest Guinea. This indicates the active circulation of the pathogen and the constant contact of the inhabitants of the region with it, which leads to epidemiological complications.
期刊介绍：
The journal deals with advances in virology in Russia and abroad. It publishes papers dealing with investigations of viral diseases of man, animals and plants, the results of experimental research on different problems of general and special virology. The journal publishes materials are which promote introduction into practice of the achievements of the virological science in the eradication and incidence reduction of infectious diseases, as well as their diagnosis, treatment and prevention. The reader will find a description of new methods of investigation, new apparatus and devices.
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