Ultrastructural characterization of extracellular vesicles produced by Encephalitozoon cuniculi-infected B-1 cells.

IF 1.2 4区医学 Q4 MICROSCOPY

Ultrastructural Pathology Pub Date : 2026-01-01 Epub Date: 2025-10-28 DOI:10.1080/01913123.2025.2580509

Alicia Herrera Gutiérrez, Rayane Cristina Bego, Diva Denelle Spadacci-Morena, Patrícia Batista Xander, Anuska Marcelino Alvares-Saraiva, Elizabeth Cristina Pérez, Uziel Castillo Velázquez, Maria Anete Lallo

引用次数: 0

Abstract

Herein, we analyzed the ultrastructure of the EVs released by E. cuniculi-infected B-1 cells or uninfected. Clusters of exosomes, also called intraluminal vesicles (ILVs), were surrounded by a membrane that was continuous with the plasma membrane of B-1 cells, characterizing the EVs known as multivesicular cargo (MVC). Migrasomes corresponded to clusters of exosomes located in the projection of the cell membrane. Ectosomes originated via the budding of the plasma membrane. To conclude, we showed that E. cuniculi-infected B-1 cells or B-1 CDP secrete large amounts of EVS especially after challenge with E. cuniculi.

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cucuuliencephalitozoon感染B-1细胞产生的细胞外囊泡的超微结构特征。

本研究分析了cucuulie感染和未感染的B-1细胞释放的ev的超微结构。外泌体簇，也称为腔内囊泡（ILVs），被一层与B-1细胞的质膜连续的膜包围，这是称为多泡货物（MVC）的ev的特征。迁移体与位于细胞膜突起处的外泌体簇相对应。外泌体起源于质膜的出芽。综上所述，我们发现感染了棘球绦虫的B-1细胞或B-1 CDP分泌大量的EVS，尤其是在棘球绦虫攻击后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrastructural Pathology 医学-病理学

CiteScore

2.00

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Ultrastructural Pathology is the official journal of the Society for Ultrastructural Pathology. Published bimonthly, we are the only journal to be devoted entirely to diagnostic ultrastructural pathology. Ultrastructural Pathology is the ideal journal to publish high-quality research on the following topics: Advances in the uses of electron microscopic and immunohistochemical techniques Correlations of ultrastructural data with light microscopy, histochemistry, immunohistochemistry, biochemistry, cell and tissue culturing, and electron probe analysis Important new, investigative, clinical, and diagnostic EM methods.