Green Synthesis, Chemical Characterization, and Antiproliferative Effect of Gold Nanoparticles Using Methanolic Extracts of Chrysophyllum cainito L. Peels.

Abstract

The article's aim was thus to evaluate the antiproliferative activity of gold nanoparticles associated with the methanolic extract of Chrysophyllum cainito in human breast cancer cell line (MCF-7), cervical cancer tissue (HeLa), and colorectal cancer cell line (HCT-116) cancer cell lines. The methanolic extract showed the presence of polyphenols and organic acids related to anticancer properties. In relation to the gold nanoparticles functionalized with the methanolic extract of C. cainito peels, these nanoparticles showed significant cytotoxic activity (p = .0001) in the HCT-116 cell line at 72 h after exposure to these. We consider this the first contribution to the use of the methanolic extract of C. cainito for the green synthesis of gold nanoparticles. In conclusion, the green synthesis of gold nanoparticles associated with C. cainito methanolic peel extract may be an interesting option for the search for new cancer treatments.